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Patrick A. Flume, John P. Clancy, George Z. Retsch-Bogart, D

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Presentation on theme: "Patrick A. Flume, John P. Clancy, George Z. Retsch-Bogart, D"— Presentation transcript:

1 Continuous alternating inhaled antibiotics for chronic pseudomonal infection in cystic fibrosis 
Patrick A. Flume, John P. Clancy, George Z. Retsch-Bogart, D. Elizabeth Tullis, Mark Bresnik, P. Alex Derchak, Sandra A. Lewis, Bonnie W. Ramsey  Journal of Cystic Fibrosis  Volume 15, Issue 6, Pages (November 2016) DOI: /j.jcf Copyright © 2016 European Cystic Fibrosis Society. Terms and Conditions

2 Fig. 1 Disposition of study subjects.
Journal of Cystic Fibrosis  , DOI: ( /j.jcf ) Copyright © 2016 European Cystic Fibrosis Society. Terms and Conditions

3 Fig. 2 Rate of protocol-defined exacerbations (primary endpoint) for subgroups of all randomized subjects. Risk ratio=risk of PDE for AZLI-treated subjects/risk for placebo-treated subjects. Journal of Cystic Fibrosis  , DOI: ( /j.jcf ) Copyright © 2016 European Cystic Fibrosis Society. Terms and Conditions

4 Fig. 3 Adjusted mean change from baseline for FEV1% Predicted (A) and Log10 P. aeruginosa CFUs/g sputum (B). Adjusted means were based on a mixed effect model repeated measures (MMRM) that included terms for treatment, visit, baseline, previous exacerbations, and treatment-by-visit interaction (for FEV1% predicted) and terms for changes from baseline at all postbaseline visits through Week 24 (for PA density). Journal of Cystic Fibrosis  , DOI: ( /j.jcf ) Copyright © 2016 European Cystic Fibrosis Society. Terms and Conditions

5 Fig. supplement Study design.
Journal of Cystic Fibrosis  , DOI: ( /j.jcf ) Copyright © 2016 European Cystic Fibrosis Society. Terms and Conditions

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