1. The Nonsteroidal Anti-inflammatory Drug Diclofenac Reduces Acid-Induced Heartburn Symptoms in Healthy Volunteers 
Takashi Kondo, Tadayuki Oshima, Toshihiko Tomita, Hirokazu Fukui, Hiroki Okada, Jiro Watari, Hiroto Miwa 
Clinical Gastroenterology and Hepatology 
Volume 13, Issue 7, Pages e1 (July 2015)
DOI: /j.cgh
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2. Figure 1
The effect of diclofenac on upper gastrointestinal symptoms. Compared with placebo, diclofenac significantly suppressed APSS of heartburn during acid perfusion (**P < .01). Compared with placebo, the other upper gastrointestinal symptoms were not affected significantly by diclofenac.
Clinical Gastroenterology and Hepatology  , e1DOI: ( /j.cgh )
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3. Figure 2
The effect of diclofenac on PGE2 generation in the esophageal mucosa and the correlation between APSS and PGE2 level. (A) In the placebo group, PGE2 levels in the esophageal biopsy samples were significantly higher after acid perfusion than before perfusion (**P < .01). In the diclofenac group, PGE2 levels significantly decreased after acid perfusion compared with the placebo group (*P < .05), and did not change from before acid perfusion (not significant). Data are presented as mean ± standard error. (B) A positive correlation was found between APSS of heartburn and increased esophageal PGE2 levels (r = 0.53, P < .05).
Clinical Gastroenterology and Hepatology  , e1DOI: ( /j.cgh )
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4. Supplementary Figure 1 Study flow diagram.
Clinical Gastroenterology and Hepatology  , e1DOI: ( /j.cgh )
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