1. Combined treatment with celecoxib and sevoflurane after global cerebral ischaemia has no additive neuroprotective effects in rats 
J.H. Seo, H.P. Park, Y.T. Jeon, Y.J. Lim, K. Nam, J.W. Hwang 
British Journal of Anaesthesia 
Volume 110, Issue 6, Pages (June 2013)
DOI: /bja/aet009
Copyright © 2013 The Author(s) Terms and Conditions

2. Fig 1
Experimental protocol for transient global cerebral IR injury in rats. After IR insults, celecoxib 2 mg kg−1 or sevoflurane 2.4% were administered according to group assignments. Occlusion=bilateral common carotid arteries occlusion with systemic hypotension.
British Journal of Anaesthesia  , DOI: ( /bja/aet009)
Copyright © 2013 The Author(s) Terms and Conditions

3. Fig 2
(a) Representative photomicrographs of hippocampal CA1 stained with H&E 7 days after transient global cerebral ischaemia in rats. Viable cells have round and pale-stained nuclei, whereas necrotic cells have pyknotic or karyolytic nuclei and show cytoplasmic shrinkage. Magnification is ×400. Scale bar=10 μm. (b) Percentages of necrotic cells in the hippocampal CA1 7 days after ischaemia. Results are median, interquartile, and full ranges (n=4 in the sham group and n=10 in the other groups). *P<0.001 compared with the sham group. †P<0.05 compared with the control group. CA1, Cornu Ammonis area 1.
British Journal of Anaesthesia  , DOI: ( /bja/aet009)
Copyright © 2013 The Author(s) Terms and Conditions

4. Fig 3
(a) Representative photomicrographs of TUNEL assay in the hippocampal CA1 of rats 7 days after transient global cerebral ischaemia. TUNEL-positive cells with dark brown colour indicate apoptotic cells. Magnification is ×400. Scale bar=10 μm. (b) Percentages of apoptotic cells in the hippocampal CA1 7 days after ischaemia. Results are median, interquartile, and full ranges (n=4 in the sham group and n=10 in the other groups). *P<0.001 compared with the sham group. †P<0.05 compared with the control group. TUNEL, terminal deoxynucleotidyl transferase-mediated deoxy-uracil triphosphate biotin in situ nick end labelling; CA1, Cornu Ammonis area 1.
British Journal of Anaesthesia  , DOI: ( /bja/aet009)
Copyright © 2013 The Author(s) Terms and Conditions

5. Fig 4
Serum TNF-α (a) and IL-1β (b) 2 h, 3 and 7 days after transient global cerebral ischaemia in rats. Results are median, interquartile, and full ranges (n=4 in the sham group and n=10 in the other groups). *P<0.001 compared with the sham group 2 h after ischaemia. †P<0.05 compared with the control group 2 h after ischaemia. ‡P<0.05 compared with the sham group 3 or 7 days after ischaemia. TNF-α, tumour necrosis factor-α; IL-1β, interleukin-1β.
British Journal of Anaesthesia  , DOI: ( /bja/aet009)
Copyright © 2013 The Author(s) Terms and Conditions