1. HSV‐1 depletes mt DNA and mt mRNA in infected Vero cells.
HSV‐1 depletes mt DNA and mt mRNA in infected Vero cells. Mt mRNA (A) and mt DNA (B) were monitored by northern and Southern blot hybridization, respectively, by using probes for COX2 and ND6. Infections with the indicated HSV‐1 strains (10 PFU/cell) were allowed to proceed for 4, 8 and 12 h. Mt mRNA (C) and mt DNA (D) loss in Vero cells and 6‐5 cells that express UL12 after HSV infection. COX2, cytochrome c oxidase subunit II; HSV‐1, herpes simplex virus type 1; mt, mitochondrial; ND6, nicotinamide adenine dinucleotide dehyrogenase subunit 6; PFU, plaque forming unit; WT, wild type.
Holly A Saffran et al. EMBO Rep. 2007;8:
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