Presentation is loading. Please wait.

Presentation is loading. Please wait.

Effect of Omalizumab on Blood Basophil Counts in Patients with Chronic Idiopathic/Spontaneous Urticaria  Sarbjit S. Saini, Theodore A. Omachi, Benjamin.

Published byBarbra Dorsey Modified over 5 years ago

Similar presentations

Presentation on theme: "Effect of Omalizumab on Blood Basophil Counts in Patients with Chronic Idiopathic/Spontaneous Urticaria  Sarbjit S. Saini, Theodore A. Omachi, Benjamin."— Presentation transcript:

1 Effect of Omalizumab on Blood Basophil Counts in Patients with Chronic Idiopathic/Spontaneous Urticaria  Sarbjit S. Saini, Theodore A. Omachi, Benjamin Trzaskoma, Henry N. Hulter, Karin Rosén, Patricia M. Sterba, Jean-Paul Courneya, Alan Lackey, Hubert Chen  Journal of Investigative Dermatology  Volume 137, Issue 4, Pages (April 2017) DOI: /j.jid Copyright © 2016 The Authors Terms and Conditions

2 Figure 1 Effects of omalizumab on laboratory and clinical parameters. Change from baseline in (a) mean whole blood histamine concentration (ng/ml), in (b) mean blood basophil percentage (by flow cytometry), and in (c) mean weekly itch severity score in a subset of patients enrolled in ASTERIA I, ASTERIA II, and GLACIAL. *P < 0.05 versus placebo. Journal of Investigative Dermatology  , DOI: ( /j.jid ) Copyright © 2016 The Authors Terms and Conditions

3 Figure 2 Whole blood histamine concentrations correlate with blood basophils. Correlation between basophil percentage and blood histamine at (a) baseline and (b) week 12 for pooled phase 3 trial patients. Journal of Investigative Dermatology  , DOI: ( /j.jid ) Copyright © 2016 The Authors Terms and Conditions

Download ppt "Effect of Omalizumab on Blood Basophil Counts in Patients with Chronic Idiopathic/Spontaneous Urticaria  Sarbjit S. Saini, Theodore A. Omachi, Benjamin."

Similar presentations

TNF-α Antagonist and Vascular Inflammation in Patients with Psoriasis Vulgaris: A Randomized Placebo-Controlled Study  Robert Bissonnette, François Harel,

TNF-α Antagonist and Vascular Inflammation in Patients with Psoriasis Vulgaris: A Randomized Placebo-Controlled Study  Robert Bissonnette, François Harel,
Chronic Idiopathic Urticaria:

Chronic Idiopathic Urticaria:
The XTEND-CIU study: Long-term use of omalizumab in chronic idiopathic urticaria  Marcus Maurer, MD, Allen Kaplan, MD, Karin Rosén, MD, PhD, Michael Holden,

The XTEND-CIU study: Long-term use of omalizumab in chronic idiopathic urticaria  Marcus Maurer, MD, Allen Kaplan, MD, Karin Rosén, MD, PhD, Michael Holden,
Suppression of Basophil FcεRI Activation by Serum from Active Chronic Idiopathic/Spontaneous Urticaria (CIU/CSU) Subjects  Patricia M. Sterba, Robert.

Suppression of Basophil FcεRI Activation by Serum from Active Chronic Idiopathic/Spontaneous Urticaria (CIU/CSU) Subjects  Patricia M. Sterba, Robert.
Thomas B. Casale, MD, Patrick H. Win, MD, Jonathan A

Thomas B. Casale, MD, Patrick H. Win, MD, Jonathan A
Similar Efficacy with Omalizumab in Chronic Idiopathic/Spontaneous Urticaria Despite Different Background Therapy  Thomas B. Casale, MD, Jonathan A. Bernstein,

Similar Efficacy with Omalizumab in Chronic Idiopathic/Spontaneous Urticaria Despite Different Background Therapy  Thomas B. Casale, MD, Jonathan A. Bernstein,
MABp1 Targeting IL-1α for Moderate to Severe Hidradenitis Suppurativa Not Eligible for Adalimumab: A Randomized Study  Theodora Kanni, Maria Argyropoulou,

MABp1 Targeting IL-1α for Moderate to Severe Hidradenitis Suppurativa Not Eligible for Adalimumab: A Randomized Study  Theodora Kanni, Maria Argyropoulou,
Surgery Versus 5% Imiquimod for Nodular and Superficial Basal Cell Carcinoma: 5-Year Results of the SINS Randomized Controlled Trial  Hywel C. Williams,

Surgery Versus 5% Imiquimod for Nodular and Superficial Basal Cell Carcinoma: 5-Year Results of the SINS Randomized Controlled Trial  Hywel C. Williams,
Shyam Joshi, MD, David A. Khan, MD 

Shyam Joshi, MD, David A. Khan, MD 
Expanding Our Understanding of Human Skin Aging

Expanding Our Understanding of Human Skin Aging
Omalizumab in patients with symptomatic chronic idiopathic/spontaneous urticaria despite standard combination therapy  Allen Kaplan, MD, Dennis Ledford,

Omalizumab in patients with symptomatic chronic idiopathic/spontaneous urticaria despite standard combination therapy  Allen Kaplan, MD, Dennis Ledford,
Predicting Chronic Spontaneous Urticaria Symptom Return After Omalizumab Treatment Discontinuation: Exploratory Analysis  Marta Ferrer, MD, PhD, Ana Giménez-Arnau,

Predicting Chronic Spontaneous Urticaria Symptom Return After Omalizumab Treatment Discontinuation: Exploratory Analysis  Marta Ferrer, MD, PhD, Ana Giménez-Arnau,
Levocetirizine and Prednisone Are Not Superior to Levocetirizine Alone for the Treatment of Acute Urticaria: A Randomized Double-Blind Clinical Trial 

Levocetirizine and Prednisone Are Not Superior to Levocetirizine Alone for the Treatment of Acute Urticaria: A Randomized Double-Blind Clinical Trial 
TNF-α Antagonist and Vascular Inflammation in Patients with Psoriasis Vulgaris: A Randomized Placebo-Controlled Study  Robert Bissonnette, François Harel,

TNF-α Antagonist and Vascular Inflammation in Patients with Psoriasis Vulgaris: A Randomized Placebo-Controlled Study  Robert Bissonnette, François Harel,
Clinical Snippets Journal of Investigative Dermatology

Clinical Snippets Journal of Investigative Dermatology
A randomized multicenter study evaluating Xolair persistence of response after long- term therapy  Dennis Ledford, MD, William Busse, MD, Benjamin Trzaskoma,

A randomized multicenter study evaluating Xolair persistence of response after long- term therapy  Dennis Ledford, MD, William Busse, MD, Benjamin Trzaskoma,
Asthma Exacerbations and Triggers in Children in TENOR: Impact on Quality of Life  Bradley E. Chipps, MD, Tmirah Haselkorn, PhD, Karin Rosén, MD, PhD,

Asthma Exacerbations and Triggers in Children in TENOR: Impact on Quality of Life  Bradley E. Chipps, MD, Tmirah Haselkorn, PhD, Karin Rosén, MD, PhD,
The Growing Burden of Invasive Melanoma: Projections of Incidence Rates and Numbers of New Cases in Six Susceptible Populations through 2031  David C.

The Growing Burden of Invasive Melanoma: Projections of Incidence Rates and Numbers of New Cases in Six Susceptible Populations through 2031  David C.
A randomized, placebo-controlled, dose-ranging study of single-dose omalizumab in patients with H1-antihistamine–refractory chronic idiopathic urticaria 

A randomized, placebo-controlled, dose-ranging study of single-dose omalizumab in patients with H1-antihistamine–refractory chronic idiopathic urticaria 
A Randomized-Controlled Trial of Oral Low-Dose Isotretinoin for Difficult-To-Treat Papulopustular Rosacea  Emilie Sbidian, Éric Vicaut, Henri Chidiack,

A Randomized-Controlled Trial of Oral Low-Dose Isotretinoin for Difficult-To-Treat Papulopustular Rosacea  Emilie Sbidian, Éric Vicaut, Henri Chidiack,

Similar presentations

Ads by Google