1. Title - Evaluation of post-operative outcome of surgically treated patients with spine metastasis
Investigator - Dr Pramod S. Chinder
Department – Musculoskeltal Oncology

2. Introduction
Surgical treatment, based on decompression of the spinal cord together with restoration of spinal stability, may reduce pain and reestablish function in cancer patients with spinal metastases.

3. If there is a major neurological deficit, disabling chronic pain or spinal instability, only surgery will reliably and quickly restore function and quality of life.

4. Research Hypothesis
Surgical decompression and stabilization of symptomatic vertebral body metastasis improves the clinical outcome of the patient, irrespective of the survival outcome

5. Rationale for the study
Problem area: In spite of numerous scoring systems, criteria's, clinical trials and guidelines, lack of standardization/protocol
Reason/need for study: To investigate the surgical decisions and outcomes of decompression and stabilization for metastatic involvement of vertebral body, so as to provide more references for the clinical treatment of this special and complex condition

6. Aim
To evaluate the outcome of surgical decompression and stabilization, in patients with symptomatic vertebral body metastasis

7. Objectives To evaluate survival To assess functional outcome
To assess change in quality of life
Factors favoring better clinical outcome

8. Literature review
“This study shows that important improvement of function can be gained by surgical treatment….”

9. Materials and Methods Inclusion criteria:
Radiological or histological evidence of vertebral metastasis from a histologically proven primary tumour
Neurological deficit / disabling pain / Instability (SIN score)
Life expectancy >3months
No active foci of local or systemic infection
Fit for anesthesia & surgery

10. Methodology All patients evaluated clinic-radiologically
Pre op VAS score, Frankel grading and
Karnofsky performance scoring
MRI for level of involvement, site of cord/nerve root compression, levels to be fixed and/or instrumented
Histological conformation when radiological diagnosis is uncertain

11. Type of study: Analytical observational study- retrospective and prospective
Sample size: 96
Precision:5%
CI: 95%
Statistics: Paired-t test- VAS scores & Karnofsky scores. Postoperative survival will be estimated by Kaplan-Meier analysis.

12. Parameters

13. Thank you 