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sSgo1, a Guardian of Centriole Cohesion

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1 sSgo1, a Guardian of Centriole Cohesion
William Y. Tsang, Brian David Dynlacht  Developmental Cell  Volume 14, Issue 3, Pages (March 2008) DOI: /j.devcel Copyright © 2008 Elsevier Inc. Terms and Conditions

2 Figure 1 A Model Illustrating the Respective Roles of Sgo1 and sSgo1 during Mitosis In metaphase, Sgo1 protects centromeric cohesin from degradation. sSgo1 may prevent premature centriole separation by itself, or it may protect spindle pole cohesin (X) from degradation. Plk1 activity antagonizes the guardian function of Sgo1 but triggers proper localization and function of sSgo1. At the onset of anaphase, cohesin, Sgo1, and possibly sSgo1 and X are destroyed, thus promoting sister chromatid separation and centriole disengagement. P denotes a phosphate group. Developmental Cell  , DOI: ( /j.devcel ) Copyright © 2008 Elsevier Inc. Terms and Conditions

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