Presentation is loading. Please wait.

Presentation is loading. Please wait.

Comparison of the effects of terfenadine with fexofenadine on nasal provocation tests with allergen  Maria-Helena Terrien, MD, François Rahm, MD, Jean-Marc.

Published byBertram Gregory Modified over 5 years ago

Similar presentations

Presentation on theme: "Comparison of the effects of terfenadine with fexofenadine on nasal provocation tests with allergen  Maria-Helena Terrien, MD, François Rahm, MD, Jean-Marc."— Presentation transcript:

1 Comparison of the effects of terfenadine with fexofenadine on nasal provocation tests with allergen 
Maria-Helena Terrien, MD, François Rahm, MD, Jean-Marc Fellrath, MD, François Spertini, MD  Journal of Allergy and Clinical Immunology  Volume 103, Issue 6, Pages (June 1999) DOI: /S (99) Copyright © 1999 Mosby, Inc. Terms and Conditions

2 Fig. 1 Shifts in allergen concentration for each patient after terfenadine or fexofenadine treatment compared with the screening phase. Results are expressed as the number of shifts in allergen concentration over the screening phase to reach the combined reaction threshold (terfenadine vs fexofenadine, P = .033 [chi-square trend]). Journal of Allergy and Clinical Immunology  , DOI: ( /S (99) ) Copyright © 1999 Mosby, Inc. Terms and Conditions

3 Fig. 2 Cumulative patient-response curve for combined threshold expressed as the percent of patients reaching combined reaction threshold at each allergen concentration (terfenadine vs fexofenadine, P = .021 [chi-square trend]). Journal of Allergy and Clinical Immunology  , DOI: ( /S (99) ) Copyright © 1999 Mosby, Inc. Terms and Conditions

4 Fig. 3 Cumulative patient-response curves for (A) nasal secretion threshold (0.5 g secretion over 10 minutes) (terfenadine vs fexofenadine, P = .008 [chi-square trend]), (B) nasal obstruction threshold as measured by AR (a decrease in at least 30% in MCA), or (C) nasal obstruction threshold as measured by PNIF (a decrease of at least 40% in nasal peak flow) (B and C, terfenadine vs fexofenadine, P > .05 [chi-square trend]). Results are expressed as the percent of patients reaching reaction threshold at each allergen concentration. Journal of Allergy and Clinical Immunology  , DOI: ( /S (99) ) Copyright © 1999 Mosby, Inc. Terms and Conditions

5 Fig. 4 Symptom scores for nasal itchiness and nasal congestion. Nasal pruritus score (range, 1 to 10) (A) and nasal congestion score (range, 1 to 10) (B) at each allergen concentration. Results are expressed as means ± SEM. Numbers on top of SEM bars indicate number of patients still tested when less than 25. *P < .05, **P < .01, terfenadine or fexofenadine vs screening phase; unpaired Student t test. Journal of Allergy and Clinical Immunology  , DOI: ( /S (99) ) Copyright © 1999 Mosby, Inc. Terms and Conditions

Download ppt "Comparison of the effects of terfenadine with fexofenadine on nasal provocation tests with allergen  Maria-Helena Terrien, MD, François Rahm, MD, Jean-Marc."

Similar presentations

Control of airborne latex by use of powder-free latex gloves

Control of airborne latex by use of powder-free latex gloves
House dust mite avoidance measures improve peak flow and symptoms in patients with allergy but without asthma: A possible delay in the manifestation of.

House dust mite avoidance measures improve peak flow and symptoms in patients with allergy but without asthma: A possible delay in the manifestation of.
In vitro lymphocyte proliferation with milk and a casein–whey protein hydrolyzed formula in children with cow's milk allergy  Philippe A. Eigenmann, MD,

In vitro lymphocyte proliferation with milk and a casein–whey protein hydrolyzed formula in children with cow's milk allergy  Philippe A. Eigenmann, MD,
Effect of 2-year placebo-controlled immunotherapy on airway symptoms and medication in patients with birch pollen allergy  Monica B. Arvidsson, MD, Olle.

Effect of 2-year placebo-controlled immunotherapy on airway symptoms and medication in patients with birch pollen allergy  Monica B. Arvidsson, MD, Olle.
A proof-of-concept study of the effect of a novel H3-receptor antagonist in allergen- induced nasal congestion  William T. Barchuk, MD, Anne Marie Salapatek,

A proof-of-concept study of the effect of a novel H3-receptor antagonist in allergen- induced nasal congestion  William T. Barchuk, MD, Anne Marie Salapatek,
Evaluation and treatment of allergic fungal sinusitis. II

Evaluation and treatment of allergic fungal sinusitis. II
The effects of upper respiratory infection on T-cell proliferation and steroid sensitivity of asthmatics  Elcio O. Vianna, MD, PhD, Jay Westcott, PhD,

The effects of upper respiratory infection on T-cell proliferation and steroid sensitivity of asthmatics  Elcio O. Vianna, MD, PhD, Jay Westcott, PhD,
Petasol butenoate complex (Ze 339) relieves allergic rhinitis–induced nasal obstruction more effectively than desloratadine  Alina F. Dumitru, MD, Mohamed.

Petasol butenoate complex (Ze 339) relieves allergic rhinitis–induced nasal obstruction more effectively than desloratadine  Alina F. Dumitru, MD, Mohamed.
Ulf Darsow, MD, Dieter Vieluf, MD, Johannes Ring, MD, PhD 

Ulf Darsow, MD, Dieter Vieluf, MD, Johannes Ring, MD, PhD 
Erika Lerch, MD, Ulrich R. Müller, MD 

Erika Lerch, MD, Ulrich R. Müller, MD 
Evaluation and treatment of allergic fungal sinusitis. II

Evaluation and treatment of allergic fungal sinusitis. II
In vitro lymphocyte proliferation with milk and a casein–whey protein hydrolyzed formula in children with cow's milk allergy  Philippe A. Eigenmann, MD,

In vitro lymphocyte proliferation with milk and a casein–whey protein hydrolyzed formula in children with cow's milk allergy  Philippe A. Eigenmann, MD,
Inhibitory effect of a leukotriene receptor antagonist (montelukast) on neurokinin a- induced bronchoconstriction  Nunzio Crimi, MD, Corrado Pagano, MD,

Inhibitory effect of a leukotriene receptor antagonist (montelukast) on neurokinin a- induced bronchoconstriction  Nunzio Crimi, MD, Corrado Pagano, MD,
Aspirin-induced urticaria and angioedema, but not bronchoconstriction, associated with cysteinyl leukotriene overproduction in 2 patients with asthma 

Aspirin-induced urticaria and angioedema, but not bronchoconstriction, associated with cysteinyl leukotriene overproduction in 2 patients with asthma 
Subjects with seasonal allergic rhinitis and nonrhinitic subjects react differentially to nasal provocation with chlorine gas  Dennis J. Shusterman, MD,

Subjects with seasonal allergic rhinitis and nonrhinitic subjects react differentially to nasal provocation with chlorine gas  Dennis J. Shusterman, MD,
Comparison of once-daily ebastine 20 mg, ebastine 10 mg, loratadine 10 mg, and placebo in the treatment of seasonal allergic rhinitis  Paul H. Ratner,

Comparison of once-daily ebastine 20 mg, ebastine 10 mg, loratadine 10 mg, and placebo in the treatment of seasonal allergic rhinitis  Paul H. Ratner,
Practice Notes from the AAAI

Practice Notes from the AAAI
Badrul A. Chowdhury, MD, PhD 

Badrul A. Chowdhury, MD, PhD 
Comparison of the efficacy of budesonide and fluticasone propionate aqueous nasal spray for once daily treatment of perennial allergic rhinitis  James.

Comparison of the efficacy of budesonide and fluticasone propionate aqueous nasal spray for once daily treatment of perennial allergic rhinitis  James.
Comparison of a nasal glucocorticoid, antileukotriene, and a combination of antileukotriene and antihistamine in the treatment of seasonal allergic rhinitis 

Comparison of a nasal glucocorticoid, antileukotriene, and a combination of antileukotriene and antihistamine in the treatment of seasonal allergic rhinitis 

Similar presentations

Ads by Google