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Pretransplantation Liver Function Impacts on the Outcome of Allogeneic Hematopoietic Stem Cell Transplantation: A Study of 455 Patients  Pere Barba, José.

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Presentation on theme: "Pretransplantation Liver Function Impacts on the Outcome of Allogeneic Hematopoietic Stem Cell Transplantation: A Study of 455 Patients  Pere Barba, José."— Presentation transcript:

1 Pretransplantation Liver Function Impacts on the Outcome of Allogeneic Hematopoietic Stem Cell Transplantation: A Study of 455 Patients  Pere Barba, José Luis Piñana, Francesc Fernández-Avilés, Jose Antonio Perez-Simón, Rodrigo Martino, Eva López-Guerrero, David Valcárcel, Montserrat Rovira, Silvana Novelli, Isabel Campos-Varela, Lucía López-Anglada, Xavier Vidal, Lucía López Corral, Enric Carreras, Jorge Sierra  Biology of Blood and Marrow Transplantation  Volume 17, Issue 11, Pages (November 2011) DOI: /j.bbmt Copyright © 2011 American Society for Blood and Marrow Transplantation Terms and Conditions

2 Figure 1 Pretransplantation hepatic underlying diseases in patients with abnormal pretransplantation liver function tests. Causes of pretransplantation hepatic disease in the 94 patients who presented at least 1 severe liver test abnormality before transplantation. Numbers in the figures represent the total number of patients and the prevalence of each category (%). Abbreviations: DILI, drug-induced liver injury; NASH, nonalcoholic steatohepatitis; AST, aspartate aminotransferase; ALT, alanine aminotransaminase; GGT, gamma glutamyl transpeptidase; AP, alkaline phosphatase. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2011 American Society for Blood and Marrow Transplantation Terms and Conditions

3 Figure 2 Impact of pretransplantation hepatic dysfunction on transplantation outcomes. Impact of the HCT-CI criteria for severe hepatic disease on NRM (A) and OS (B). Dashed lines indicate severe abnormalities of liver function tests; continuous lines indicate normal or mild liver function tests, according to the original definition of the HCT-CI. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2011 American Society for Blood and Marrow Transplantation Terms and Conditions


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