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Figure 4 The molecular configuration of the CD20 molecule

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Presentation on theme: "Figure 4 The molecular configuration of the CD20 molecule"— Presentation transcript:

1 Figure 4 The molecular configuration of the CD20 molecule
Figure 4 | The molecular configuration of the CD20 molecule. CD20 is a tetra-transmembrane protein that essentially remains on the membrane of B cells without dissociation or internalization upon antibody binding. CD20 has small and large extracellular loops. The binding sites of CD20 monoclonal antibodies, rituximab and ofatumumab, are indicated. Rituximab binds an epitope on the large loop only, whereas ofatumumab specifically recognizes an epitope encompassing both the small and large extracellular loops of the CD20 molecule. Ruggenenti, P. et al. (2017) Treatment of membranous nephropathy: time for a paradigm shift Nat. Rev. Nephrol. doi: /nrneph

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