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Profiling of Oncogenic Driver Events in Lung Adenocarcinoma Revealed MET Mutation as Independent Prognostic Factor  Sai F. Yeung, BSc, Joanna H.M. Tong,

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Presentation on theme: "Profiling of Oncogenic Driver Events in Lung Adenocarcinoma Revealed MET Mutation as Independent Prognostic Factor  Sai F. Yeung, BSc, Joanna H.M. Tong,"— Presentation transcript:

1 Profiling of Oncogenic Driver Events in Lung Adenocarcinoma Revealed MET Mutation as Independent Prognostic Factor  Sai F. Yeung, BSc, Joanna H.M. Tong, PhD, Peggy P.W. Law, MPhil, Lau Y. Chung, AD, Raymond W.M. Lung, PhD, Carol Y.K. Tong, MPhil, Chit Chow, PhD, Anthony W.H. Chan, FRCPA, Innes Y.P. Wan, FRCS, Tony S.K. Mok, MD, Ka F. To, FRCPA  Journal of Thoracic Oncology  Volume 10, Issue 9, Pages (September 2015) DOI: /JTO Copyright © 2015 International Association for the Study of Lung Cancer Terms and Conditions

2 FIGURE 1 A, Frequencies of known oncogenic drivers on RTK/RAS/PI3K axis in lung adenocarcinoma (n = 149). Co-mutation plot for oncogenic driver stratified according to (B) gender and (C) smoking status. Journal of Thoracic Oncology  , DOI: ( /JTO ) Copyright © 2015 International Association for the Study of Lung Cancer Terms and Conditions

3 FIGURE 2 MET alterations in lung adenocarcinoma. A, Schematic illustration of the location of MET exon 14 splice site mutations found in this study. B, Representative images of MET FISH analysis. C, Representative images showing negative, moderate, and strong MET protein expression by immunohistochemistry. Journal of Thoracic Oncology  , DOI: ( /JTO ) Copyright © 2015 International Association for the Study of Lung Cancer Terms and Conditions

4 FIGURE 3 Kaplan–Meier survival curve for overall survival in lung adenocarcinoma according to (A) EGFR mutation and (B) MET mutation. Journal of Thoracic Oncology  , DOI: ( /JTO ) Copyright © 2015 International Association for the Study of Lung Cancer Terms and Conditions

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