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W. Sougakoff  Clinical Microbiology and Infection 

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Presentation on theme: "W. Sougakoff  Clinical Microbiology and Infection "— Presentation transcript:

1 Molecular epidemiology of multidrug-resistant strains of Mycobacterium tuberculosis 
W. Sougakoff  Clinical Microbiology and Infection  Volume 17, Issue 6, Pages (June 2011) DOI: /j x Copyright © 2011 European Society of Clinical Infectious Diseases Terms and Conditions

2 FIG. 1 Geographical distribution of the lineages of multidrug-resistant strains (n = 98) received in 2009–2010 by the French National Reference Centre for mycobacteria (CNR MyRMA), according to the country of birth of the patients. The diameters of coloured circles are proportional to the numbers of strains belonging to a given lineage. The colour indicates the mycobacterial interspersed repetitive unit (MIRU)-24-defined lineage to which each strain is related: Beijing is red, T is dark blue, T1-Ghana is light green, Haarlem is green, LAM is dark green, Cameroon is yellow–orange, TUR is blue, S is light blue, Dehli/CAS is green–khaki, and undetermined types are pink and violet. Clinical Microbiology and Infection  , DOI: ( /j x) Copyright © 2011 European Society of Clinical Infectious Diseases Terms and Conditions

3 FIG. 2 Minimum spanning tree based on the diversity of the 24-locus mycobacterial interspersed repetitive unit (MIRU)-variable numbers of tandem repeats (VNTR) results for a representative sample of multidrug-resistant strains received at the French National Reference Centre (CNR MyRMA) (2009–2010). The main clonal complexes (CCs) are indicated (a CC consists of strains that differ from each other by a single locus change): CC1, Beijing; CC2, probably Haarlem; CC3, T1-Ghana; CC4, T2-T3; CC5, S. Clusters are indicated by filled circles. The tree was drawn by using the MIRU-VNTRplus website. Clinical Microbiology and Infection  , DOI: ( /j x) Copyright © 2011 European Society of Clinical Infectious Diseases Terms and Conditions


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