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Impact of polymorphism of Multidrug Resistance-associated Protein 1 (ABCC1) gene on the severity of cystic fibrosis  Andrea Mafficini, Myriam Ortombina,

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Presentation on theme: "Impact of polymorphism of Multidrug Resistance-associated Protein 1 (ABCC1) gene on the severity of cystic fibrosis  Andrea Mafficini, Myriam Ortombina,"— Presentation transcript:

1 Impact of polymorphism of Multidrug Resistance-associated Protein 1 (ABCC1) gene on the severity of cystic fibrosis  Andrea Mafficini, Myriam Ortombina, Isabelle Sermet-Gaudelius, Patrick Lebecque, Teresinha Leal, Patrizia Iansa, Gregory Reychler, Karin Dahan, Xaviers Pepermans, Gerard Lenoir, Anissa Leonard, Claudio Sorio, Baroukh Assael, Paola Melotti  Journal of Cystic Fibrosis  Volume 10, Issue 4, Pages (July 2011) DOI: /j.jcf Copyright © 2011 European Cystic Fibrosis Society. Terms and Conditions

2 Fig. 1 Age at chronic P. aeruginosa infection according to ABCC1 genotype. Kaplan–Meier plots relative to age at chronic infection by P. aeruginosa in patients with CC, GG and GC alleles (n=103) show different trends for CC versus GG and GC (P= and P= respectively). Journal of Cystic Fibrosis  , DOI: ( /j.jcf ) Copyright © 2011 European Cystic Fibrosis Society. Terms and Conditions

3 Fig. 2 Lung function decline according to ABCC1 genotypes. Kaplan–Meier plots relative to age at first episode with FEV1 <60% of predicted value in patients with CC, GG and GC alleles (n=153) are shown. The overall difference between the three curves is also significant (P=0.024), with a significant trend towards worse prognosis from GG to CC (P=0.015). Journal of Cystic Fibrosis  , DOI: ( /j.jcf ) Copyright © 2011 European Cystic Fibrosis Society. Terms and Conditions

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