1. MicroRNAs in Pathogenesis, Diagnosis, and Treatment of Gastroesophageal Cancers 
Jee Hoon Song, Stephen J. Meltzer 
Gastroenterology 
Volume 143, Issue 1, Pages e2 (July 2012)
DOI: /j.gastro
Copyright © 2012 AGA Institute Terms and Conditions

2. Figure 1
Influences of miRNAs on the cell cycle in gastroesophageal (GE) cancers. miRNAs that are up-regulated in tumors inhibit cell cycle-inhibitory genes, such as SMAD4, CDX2, p21, p57, and p27. Conversely, miRNAs that are downregulated in tumors inhibit cell cycle-stimulatory genes, such as c-myc, cyclin E, E2F1, ΔNp63, and FGFRL1. miRNAs that are dysregulated in gastric cancer (GC) only are indicated in blue boxes; those involved in esophageal cancer (EC) only are contained in pink boxes; and thoseimplicated in both (all GE cancers) are in the purple box.
Gastroenterology  , e2DOI: ( /j.gastro )
Copyright © 2012 AGA Institute Terms and Conditions

3. Figure 2
Influences of miRNAs on apoptosis in gastroesophageal (GE) cancers. miRNAs that are up-regulated in tumors inhibit pro-apoptotic genes, such as Bim, EGR2, and RUNX3. On the other hand, miRNAs that are downregulated in tumors inhibit anti-apoptotic genes, such as Mcl-1, Bcl-2, MIF, ζ and components of the EGFR-PI3K-Akt signaling pathway. miRNAs that are dysregulated in gastric cancer (GC) only are indicated in blue boxes; and those implicated in both (all GE cancers) are in the purple box.
Gastroenterology  , e2DOI: ( /j.gastro )
Copyright © 2012 AGA Institute Terms and Conditions

4. Figure 3
Influences of miRNAs on invasion and metastasis in gastroesophageal (GE) cancers. miRNAs that are up-regulated in tumors inhibit invasion/metastasis-inhibitory genes, such as E-cadherin, ALCAM, EPB41L3, RECK, and KLF4. In opposition, miRNAs that are down-regulated in tumors inhibit invasion/metastasis-promoting genes, such as ZEB1/ZEB2, MYH9, and components of the Bcl-w-PI3K-Akt-SP1 signaling pathway. miRNAs that are dysregulated in gastric cancer (GC) only are indicated in blue boxes; and those involved in esophageal cancer (EC) only are contained in pink boxes.
Gastroenterology  , e2DOI: ( /j.gastro )
Copyright © 2012 AGA Institute Terms and Conditions