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Protein Basics Protein function Protein structure
Protein Basics Notes Protein Basics Protein function Protein structure Primary Amino acids Linkage Secondary Tertiary Quaternary Effect of DNA Mutation
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Protein Function in Cell
Enzymes Catalyze biological reactions Structural role Cell wall Cell membrane Cytoplasm
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DNA RNA Protein Trait
A. Bio-molecules are the basis of traits DNA RNA Protein Trait • Traits represent organisms': - Structure - Function • Proteins determine structure and function • DNA codes for proteins that convey traits
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Protein Basics Notes Frank Lloyd Wright
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Levels of Protein Structure
Protein Basics Notes Levels of Protein Structure The Shape it takes depends on the order of the Amino Acids
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From our last set of notes: Translation
Second stage of protein production mRNA is on a ribosome
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Primary structure = order of amino acids in the protein chain
Protein Basics Notes Primary structure = order of amino acids in the protein chain
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Membrane proteins have adapted to hydrophobic environments
Protein Basics Notes Membrane proteins have adapted to hydrophobic environments
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Secondary structure = local folding of residues into regular patterns
Protein Basics Notes Secondary structure = local folding of residues into regular patterns
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Tertiary structure = global folding of a protein chain
Protein Basics Notes Tertiary structure = global folding of a protein chain
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Tertiary structures are quite varied
Protein Basics Notes Tertiary structures are quite varied
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Quaternary structure = Higher-order assembly of proteins
Protein Basics Notes Quaternary structure = Higher-order assembly of proteins
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Example of quaternary structure - Sir1/Orc1 heterodimer
Protein Basics Notes Example of quaternary structure - Sir1/Orc1 heterodimer Example is Sir1/Orc1 complex solved at UW: Hou, Bernstein, Fox, and Keck (2005) Proc. Natl. Acad. Sci. 102,
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Ex: Quaternary structures –
Protein Basics Notes Ex: Quaternary structures – You don’t need to memorize these types Tetramer Hexamer Filament SSB DNA helicase Recombinase Allows coordinated Allows coordinated DNA binding Allows complete DNA binding and ATP hydrolysis coverage of an extended molecule
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Protein: The Machinery of Life
NH2-Val-His-Leu-Thr-Pro-Glu-Glu- Lys-Ser-Ala-Val-Thr-Ala-Leu-Trp- Gly-Lys-Val-Asn-Val-Asp-Glu-Val- Gly-Gly-Glu-….. “Life is the mode of existence of proteins, and this mode of existence essentially consists in the constant self-renewal of the chemical constituents of these substances.” Friedrich Engles, 1878
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DNA Mutation Function Students know how mutations in the DNA sequence of a gene may or may not affect the expression of the gene or the sequence of amino acids in an encoded protein.
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