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Chronic Cholestasis with Dilation of Intrahepatic Bile Duct Related to Administration of Ceritinib  Taizou Hirano, MD, PhD, Mitsuhiro Yamada, MD, PhD,

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Presentation on theme: "Chronic Cholestasis with Dilation of Intrahepatic Bile Duct Related to Administration of Ceritinib  Taizou Hirano, MD, PhD, Mitsuhiro Yamada, MD, PhD,"— Presentation transcript:

1 Chronic Cholestasis with Dilation of Intrahepatic Bile Duct Related to Administration of Ceritinib 
Taizou Hirano, MD, PhD, Mitsuhiro Yamada, MD, PhD, Masakazu Ichinose, MD, PhD  Journal of Thoracic Oncology  Volume 12, Issue 8, Pages e123-e125 (August 2017) DOI: /j.jtho Copyright © 2017 International Association for the Study of Lung Cancer Terms and Conditions

2 Figure 1 Clinical course and laboratory data in this case. CTRX, ceftriaxone; ALP, alkaline phosphatase; γGTP, γ-guanosine triphosphate; CRP, C-reactive protein; MRCP, magnetic resonance cholangiopancreatography; T-BIL, total bilirubin; AST, aspartate transaminase; ALT, alanine transaminase. Journal of Thoracic Oncology  , e123-e125DOI: ( /j.jtho ) Copyright © 2017 International Association for the Study of Lung Cancer Terms and Conditions

3 Figure 2 Clinical imaging examinations in this case. Contrast-enhanced computed tomography (A), magnetic resonance imaging (T2 weighted image) (B), and magnetic resonance cholangiopancreatography (C) were performed 54 days after admission. Computed tomography showed dilation of the intrahepatic bile duct. Magnetic resonance imaging and magnetic resonance cholangiopancreatography also showed dilation of the intrahepatic bile duct with periportal edema, suggesting inflammation and edema of Glisson's capsule. These radiological examinations did not suggest obstructions, including stone or tumor in the bile duct. Journal of Thoracic Oncology  , e123-e125DOI: ( /j.jtho ) Copyright © 2017 International Association for the Study of Lung Cancer Terms and Conditions

4 Figure 3 Histopathological findings of a liver biopsy performed 59 days after admission. Histopathological findings in the liver (hematoxylin and eosin) (A) and immunostainng for cytokeratin 7 (B) revealed proliferation of bile ductules and invasion of neutrophils (arrow), which were consistent with the presence of drug-induced cholestasis but did not suggest the presence of other causes, including primary sclerosing cholangitis, primary biliary cirrhosis, autoimmune hepatitis, and intrahepatic calculosis. (Bar = 100 μm.) Journal of Thoracic Oncology  , e123-e125DOI: ( /j.jtho ) Copyright © 2017 International Association for the Study of Lung Cancer Terms and Conditions

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