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Pathophysiology of severe asthma

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1 Pathophysiology of severe asthma
William W. Busse, MDa, Susan Banks-Schlegel, PhDb, Sally E. Wenzel, MDc  Journal of Allergy and Clinical Immunology  Volume 106, Issue 6, Pages (December 2000) DOI: /mai Copyright © 2000 Mosby, Inc. Terms and Conditions

2 Fig. 1 Examples of small airway tissue (hematoxylin-eosin staining) from patients with severe asthma and normal control subjects. A, Open lung biopsy specimen of a living patient with severe asthma demonstrates markedly folded bronchial epithelia and mucosa, thickened airway wall, and epithelial cell aggregate in the airway lumen. B, Autopsy specimen from a patient with fatal severe asthma demonstrating goblet cell hyperplasia and eosinophilic inflammation. The airway lumen is occupied with a mucus plug. C, A normal small airway from a normal subject’s postmortem lung (original magnification, 100×). Journal of Allergy and Clinical Immunology  , DOI: ( /mai ) Copyright © 2000 Mosby, Inc. Terms and Conditions


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