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Published byIndra Oesman Modified over 6 years ago
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Expression of α4β1 and αvβ3 integrins in the endometrium of women using the T200 copper intrauterine device Ricardo Savaris, M.D., Cláudio Galleano Zettler, M.D., Arnaldo Nicola Ferrari, M.D. Fertility and Sterility Volume 74, Issue 6, Pages (December 2000) DOI: /S (00)
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Figure 1 Immunohistochemical localization of α4 and β3 integrin subunits in the endometrium from controls and from copper IUD T200 users. (A), A positive staining for mouse anti-human β3-subunit in the endometrial gland (arrow) on day 8 after ovulation in a control patient’s menstrual cycle. (B), A positive staining for α4 in a gland in an IUD user (arrow) and negative expression in the lumen as expected (arrow head). (C), The same sample stained for β3. Observe the negative expression in the gland (asterisk) and in the lumen (arrowhead). (D), A patient with negative β3 in glands (asterisk) and lumen (arrowhead), but with a positive-staining stromal epithelium (white arrow). (Original magnification, ×200.) Savaris. Endometrial integrin in IUD T200 users. Fertil Steril 2000. Fertility and Sterility , DOI: ( /S (00) )
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Figure 2 Immunohistochemical staining (HSCORE) and distribution of endometrial specimens obtained from controls (n = 13) and IUD users (n = 13). Results are means ± SD. □ = IUD. = control. Savaris. Endometrial integrin in IUD T200 users. Fertil Steril 2000. Fertility and Sterility , DOI: ( /S (00) )
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Figure 3 Percentage of positive immunoperoxidase staining (HSCORE > 0.7) for α4 and β3 integrin subunits in luminal and glandular endometrium in copper IUD users (n = 13) and controls (n = 13). □ = IUD. = control. ∗Fisher’s exact test = 0.01. Savaris. Endometrial integrin in IUD T200 users. Fertil Steril 2000. Fertility and Sterility , DOI: ( /S (00) )
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