1. Guardians of the Gut: Newly Appreciated Role of Epithelial Toll-Like Receptors in Protecting the Intestine 
Matam Vijay-Kumar, Andrew T. Gewirtz 
Gastroenterology 
Volume 135, Issue 2, Pages (August 2008)
DOI: /j.gastro
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2. Figure 1
Chronic epithelial TLR activation promotes expression of fecal IgA. Constitutive activation of epithelial TLR signaling results in NF-κB–mediated production of B-cell chemoattractants, CCL20 and CCL28, that recruit B lymphocytes. TLR signaling may also result in production of APRIL, which promotes B-cell differentiation into IgA-producing plasma cells (PC).
Gastroenterology  , DOI: ( /j.gastro )
Copyright © 2008 AGA Institute Terms and Conditions

3. Figure 2
TLR signaling can promote both survival and tumor necrosis. Activation of TLR-5 in carcinomas may simultaneously (1) promote cancer cell survival via activating NF-κB–mediated anti-apoptotic gene expression and (2) recruit neutrophils that promote tumor necrosis. Whether necrosis or survival prevails will likely depend on the specific characteristics of a particular tumor.
Gastroenterology  , DOI: ( /j.gastro )
Copyright © 2008 AGA Institute Terms and Conditions