1. Fig. 3. 3RMR response to graded ischemia ex vivo.
3RMR response to graded ischemia ex vivo. (A) As coronary flow rate (CFR) was incrementally decreased from baseline in a flow-controlled retrograde Langendorff perfusion experiment, myocardial tissue oxygen tension (tPO2, gray bars) decreased from a baseline of 97.3 ± 5.6 mmHg (mean ± SD) to 1.4 ± 1.3 mmHg [P < , repeated-measures analysis of variance (ANOVA)]. Contemporaneously, the 3RMR increased from a baseline of 22 ± 3% during full perfusion to 54 ± 14% during complete ischemia (P < 0.001, repeated-measures ANOVA). Data are means, and error is SD. (B) Increases in 3RMR were nonlinearly (single-phase decay) associated with decreases in contractility (dP/dTmax). Data are means of each 10-min observation period. The line is a single-phase decay line with 95% confidence interval (CI) of regression line; P < , Spearman correlation coefficient r = −0.88; r2 = (C) Contractility (dP/dTmax) was linearly associated with tPO2. Data are means of each 10-min observation period. Line is a linear regression line with 95% CI of regression line; P < , Pearson correlation coefficient r = −0.88; r2 = 0.71; n = 10 rodents.
Dorothy A. Perry et al., Sci Transl Med 2017;9:eaan0117
Published by AAAS