1. Toward scaffold-based meniscus repair: effect of human serum, hyaluronic acid and TGF-ß3 on cell recruitment and re-differentiation 
U. Freymann, M. Endres, U. Goldmann, M. Sittinger, C. Kaps 
Osteoarthritis and Cartilage 
Volume 21, Issue 5, Pages (May 2013)
DOI: /j.joca
Copyright © 2013 Osteoarthritis Research Society International Terms and Conditions

2. Fig. 1
A and B: Migration of human meniscus-derived cells subjected to different HS concentrations. The mean number of migrated cells per HS concentration is presented for the cell preparation of each individual donor (three donors in total) and error bars represent 95% CI (lower/upper limit) (A). The MI is given as the median with the ends of the boxes defining the 25th and 75th percentiles and error bars defining the 10th and 90th percentiles. Asterisks represent significant differences compared to the control group (*P ≤ 0.001) (B).
Osteoarthritis and Cartilage  , DOI: ( /j.joca )
Copyright © 2013 Osteoarthritis Research Society International Terms and Conditions

3. Fig. 2
Real-time gene expression analysis of selected genes. Fold change analysis of chondrocytic marker genes like type I collagen, type II and type IX collagen, aggrecan and COMP is shown in meniscus-derived high-density micro-mass cultures compared to untreated controls. The mean of five individual cell preparations is plotted and error bars represent 95% CI (lower/upper limit). Asterisks represent significant differences compared to the control group.
Osteoarthritis and Cartilage  , DOI: ( /j.joca )
Copyright © 2013 Osteoarthritis Research Society International Terms and Conditions

4. Fig. 3
A–L: Histological and immune-histochemical staining of untreated and stimulated meniscus-derived cell pellet sections at day 28. The untreated controls revealed no proteoglycans (A), whereas cell pellets treated with TGF-ß3 (D), hyaluronan (G) and HS (H) showed a proteoglycan-rich matrix stained by alcian blue. Serum-free controls (B) showed no type I collagen formation within the cell pellet, whereas type I collagen is present when pellets were cultured in the presence of HA (H), TGF-ß3 (E) and HS (K). Serum-free controls (C) and cell pellets treated with hyaluronan (I) and HS (L) showed no type II collagen formation within the cell pellet, whereas type II collagen is present when pellets are cultured in the presence of TGF-ß3 (F).
Osteoarthritis and Cartilage  , DOI: ( /j.joca )
Copyright © 2013 Osteoarthritis Research Society International Terms and Conditions