1. MUSCLE STRUCTURE AND PHYSIOLOGY
J. Rosenbluth, April 2012

2. MUSCLE Skeletal muscle fibers Gross properties of skeletal muscle
Contraction mechanism
Excitation-contraction coupling
Gross properties of skeletal muscle
Pathology/Clinical examples

3. Myofibrils

4. Skeletal muscle band pattern

5. Double “antiparallel” array of myofilamnts (H.E.Huxley)

6. Sliding filament model

7. Myosin filament formation

8. Low-angle X-ray diffraction of skeletal muscle (meridional pattern)

9. Decorated F-actin

10. Antiparallel array of myofilaments

11. Double hexagonal array (vertebrate skeletal muscle)

12. Crossbridge position during relaxation (top) vs contraction (bottom)

13. Cross-bridge Cycle
Attached
Released
Cocked
Force generating

15. Triads (amphibian)

16. Skeletal muscle triad (amphibian)

17. Triad structure

18. Actin filament with Tr and Tm

19. Tropomyosin movement

21. Pennate Muscles

22. Length-Tension
Relationship

23. Load-Velocity Relationship

24. Twitch vs Tetanic Tension

25. Fiber types (cat gastrocnemius)

26. Twitch contraction times

27. Skeletal Muscle Fatigue

30. “Winging” (facio-scapulo-humeral dystrophy)

31. “Pseudohypertrophy” (Duchenne dystrophy)

32. Charcot-Marie-Tooth disease

33. Spinal muscular atrophy