1. Overview AMR international initiatives – The Landscape
Laura Marin
JPIAMR Head of Secretariat
Swedish Research Council
MB Meeting 2018
Leuven, 23 October 2018

2. A Global Organisation 27 Countries have joined forces
The European Commission (DG Research) is a full non voting member

3. International collaboration
ORGANISATIONS
FUNDERS
UNGA, IAGC & Call for Action
G7 Resolutions
G20 Resolutions
EU Council Conclusions
AMR Global R&D Hub

4. Activities at International Level
UNGA and IACG
“IACG on AMR subgroup Innovation, R&D and Access”. They are doing an analysis of AMR R&D and access gaps and challenges. They published a discussion paper this summer and prepare UNGA recommendations for September 2019.
UN AMR call for Action
JPIAMR participated in the last event Berlin, October 2017
JPIAMR has been approached to be a co-host of the event in Ghana, November 2018
WHO
Global Action Plan
JPIAMR has been approach regarding pre-clinical pipeline analysis
Meeting in January with WHO Europe
TATFAR: Atlanta, March 2018
Panel discussion regarding future synergies among international initiatives

5. Activities at International Level
G7, G20 resolutions
Argentina October 2018: G20 mentions JPIAMR together with GARDP, UNITAD, CARB-X and the TB-Alliance, welcoming the work of these leading international initiatives.
AMR R&D Global Hub
Secretariats meeting, Stockholm, September 2018
Collaboration: data sharing for AMR investments dashboard
PEW
SPARK database
Wellcome
Observers at SEDRIC (Surveillance)

6. Activities at European Level
9FP – activities related to GPC and JPIs Chairs group
Discussions on EC 9FP Horizon Europe
New category for JPIs and new criteria; European Partnerships
Future 9FP instruments: CSAs to support JPIs and call offices, New instrument? Co-programme? Co-fund?
Drafts December 2018, candidates mid-2019
Common seminar JPIs on the future of
Joint Programming
The JPI chairs Forum September 20th Vienna.
Joint collaboration
Joint session at ECCMID
Joint article
EAAD
Relations to AMR European Initiates
European Joint Programme One Health in Zoonosis
Partner of their Stakeholders Forum
DG Sante Joint Action ”JAMRAI”

7. ANTIBIOTIC DRUG DEVELOPMENT AND INTERNATIONAL FUNDING INITIATIVES
International Collaboration among Funders
ANTIBIOTIC DRUG DEVELOPMENT AND INTERNATIONAL FUNDING INITIATIVES
Phase I
Phase II
Phase III
Basic Science
Pre-clinical
Market
JPIAMR
EU National Science Research Agencies
EC FP / ERC
EC - IMI / ND4BB
US BARDA
US NIH / NIAID
Wellcome Trust
CARB-X
GARDR-P
EIB’s InnovFin
UK / China Global Innovation Fund
REPAIR REPAIR Novo Holdings Fund
Existed Prior 2016
Since 2017

8. Major AMR funding initiatives
Prospect Budget
USD 502m ( )
Euro 234m ( )
Euro 270m ( )
USD 165m ( )
Euro 85m/800 m ( )
Products
Novel therapeutics, diagnostics, preventatives, devices
Novel therapeutics, diagnostics, surveillance, prevention, stewardship
Novel therapeutics,
Optimize antibiotics,
Develop combinations
Novel therapeutics, companion diagnostics
Novel therapeutics
Pathogens
High priority defined by WHO and CDC, largely Gram-negatives
WHO priority pathogens
Member state national priorities
WHO priority pathogen list, especially Gram-negatives
High priority defined by WHO and CDC
E. coli, K. pneumoniae, P. aeruginosa and A. baumannii
Stages of development
Hit-to-lead through end of Phase 1
Discovery research
Any stage of development to patient access
Lead optimization through end of Phase 1
Geography
Global
Europe & U.S.
Europe
Funding instruments
Non-dilutive funding and expert support
Research project grants, Networks, Virtual research institute
Sponsor role (preclinical studies & clinical trials)
Convertible loans and royalty-based
Financial, in-kind and expertise support
Funding allotments
Flexible, with milestones; >30% cost share
Direct funding 1m to 5m
Direct funding and flexible partnerships
USD 1m to 15m
Flexible
Conditions
Stewardship and market access requirements
Stewardship and access. Consider in/out licencing
Stewardship and access requirements (in progress)
Limited compensation when value generated

9. Activities at International Level
Relations with international funders: CARB-X, GARP-D, Wellcome…
Global AMR Funders Forum, London, December 2017
TBC, Brussels, February 2018
Joint MoU educational programmes
Bootcamps
Sessions at conferences
CARB-X; GARDP; JPIAMR; REPAIR Novo fund

10. Thank you!
@JPIAMR