1. HHV 5014 NUTRACEUTICAL FORMULATION TECHNOLOGY
UNIT 7: LIQUID DOSAGE FORM
SUB UNIT 7.5: DISPERSED SYSTEM (SUSPENSION)
DAUS FIZA SOFIA IJA

2. INTRODUCTION
Dispersed system is defined as a heterogeneous two phase system in which internal (dispersed, discontinuous) phase is distributed or dispersed within the continuous (external) phase or vehicle.
The internal and external phase may be solids, liquids and also gases.
Eg: suspensions, emulsions, aerosol.

4. WHY NEED DISPERSION? For improving product stability
Ease of administration and flexibility in administration of a range of doses
For masking unpleasant taste of product

5. SUSPENSIONS
Suspensions defined as preparations containing finely divided drug particles distributed somewhat uniformly throughout a vehicle in which the drug exhibits a minimum degree of solubility.

6. REASONS FOR SUSPENSION
For improving product stability.
Ease of administration and flexibility in administration of a range of doses.

7. FEATURES DESIRED IN PHARMACEUTICAL SUSPENSION
Particles should settle slowly and should be readily re-dispersed upon shaking of the container.
The particle size of the suspension should remain fairly constant throughout long periods of undisturbed standing.
The suspension should pour readily and evenly from its container.

8. DISPERSED PHASE: PHYSICAL FEATURES
Particle diameter is 1 to 50 µm
Particle size reduction is accomplished by dry milling:
Micro pulverization – µm
Fluid energy grinding (jet milling or micronization) – under 10 µm

9. TYPE OF DISPERSION
Oral
Injection
Opthalmic
Topical
Rectal

10. Oral
Ready to use
Dry powders for reconstitution
Uses: Antacid, Anthelmintic, Antibacterial
Injection
Articles must exhibit “SYRINGEABILITY”
The product must have the ability to be successfully administered by a syringe and appropriate needle.

11. Opthalmic
Particle size must not exceed 10 microns
Particles must be “impalpable”
Topical
Fine particles (impalpable) are desired to avoid grittiness when applied to the skin.
The smaller the particle size, the greater the covering and protective power of the preparation.

12. Rectal
Barium Sulfate for Suspension
May be employed orally or rectally for diagnostic visualization

13. DISPERSION EQUIPMENT
MIXER
HIGH SPEED DISPENSER

14. ROTOR STATOR MIXERS
COMBINATION MIXERS

15. IN LINE MIXER

16. THANK YOU