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Volume 151, Issue 5, Pages 870-878.e3 (November 2016)
Clinical and Molecular Characteristics of Post-Colonoscopy Colorectal Cancer: A Population-based Study Elena M. Stoffel, Rune Erichsen, Trine Frøslev, Lars Pedersen, Mogens Vyberg, Erika Koeppe, Seth D. Crockett, Stanley R. Hamilton, Henrik T. Sørensen, John A. Baron Gastroenterology Volume 151, Issue 5, Pages e3 (November 2016) DOI: /j.gastro Copyright © 2016 AGA Institute Terms and Conditions
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Figure 1 Flowchart of CRC cases diagnosed nationwide in Denmark during 2007–2011, showing post-colonoscopy (PC) vs diagnostic colonoscopy (DC) cases, and a hospital-based subsample of PC cases. Gastroenterology , e3DOI: ( /j.gastro ) Copyright © 2016 AGA Institute Terms and Conditions
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Figure 2 Restricted cubic spline analyses showing variation in the post-colonoscopy (PC)/diagnostic colonoscopy (DC) prevalence ratio (PR) of patient and tumor characteristics over time since prior colonoscopy, adjusted for sex and age (PR = solid line, 95% CI = dashed lines). (A) PR of proximal tumor location, (B) PR of MMR. PR of MMR stratified by tumor location proximal (C) and distal (D). Splines have 5 knots at 1, 3, 6, 9, and 12 years. MMR, mismatch repair. Gastroenterology , e3DOI: ( /j.gastro ) Copyright © 2016 AGA Institute Terms and Conditions
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Figure 3 Distribution of molecular characteristics among hospital-based PC cases, by interval between colonoscopy and CRC diagnosis (n = 85). NOTE: Figures are not proportional between time intervals. Area exterior to microsatellite stable (MSS) circle represents microsatellite instability-high (MSI-Hi) tumors. Gastroenterology , e3DOI: ( /j.gastro ) Copyright © 2016 AGA Institute Terms and Conditions
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Supplementary Figure 1 Prevalence of proximal tumor location (A) and dMMR (B) among post-colonoscopy CRC cases (n = 628 cases with IHC results), stratified by sex. Blue, female; red, male. Dashed lines indicate prevalence of either factor among diagnostic colonoscopy cases for 3926 females and 4340 males; error bars indicate 95%. Gastroenterology , e3DOI: ( /j.gastro ) Copyright © 2016 AGA Institute Terms and Conditions
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