Presentation is loading. Please wait.

Presentation is loading. Please wait.

Allergen sensitization in a birth cohort at midchildhood: Focus on food component IgE and IgG4 responses  Jeffrey M. Wilson, MD, PhD, Lisa Workman, BA,

Published byWilla Moore Modified over 5 years ago

Similar presentations

Presentation on theme: "Allergen sensitization in a birth cohort at midchildhood: Focus on food component IgE and IgG4 responses  Jeffrey M. Wilson, MD, PhD, Lisa Workman, BA,"— Presentation transcript:

1 Allergen sensitization in a birth cohort at midchildhood: Focus on food component IgE and IgG4 responses  Jeffrey M. Wilson, MD, PhD, Lisa Workman, BA, Alexander J. Schuyler, BS, BA, Sheryl L. Rifas-Shiman, MPH, Emily C. McGowan, MD, Emily Oken, MD, MPH, Diane R. Gold, MD, MPH, Robert G. Hamilton, PhD, Thomas A.E. Platts-Mills, MD, PhD  Journal of Allergy and Clinical Immunology  Volume 141, Issue 1, Pages e5 (January 2018) DOI: /j.jaci Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 A, IgE sensitization to inhalant and food allergen extracts in 6- to 10-year-olds (n = 616) as measured by ImmunoCAP. B, Comparison of IgE results from microchip assay with results from the extract assay. C, Comparison of food-specific components with ImmunoCAP singleplex and ISAC. Class sensitization (on x-axis) was determined by extract testing and statistics reflect the χ2 test with Yates correction. Journal of Allergy and Clinical Immunology  , e5DOI: ( /j.jaci ) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 A, Representative results of samples that were tested for IgE and IgG4 to cow's milk and peanut components by ImmunoCAP, and for IgE to components by ISAC. B, Specific IgG4 levels from samples that were positive to the component-relevant food specific IgE by extract testing where threshold of detection of specific IgG4 was 0.07 μg/mL. Data represent geometric means where error bars are the 95% CI. Values less than the threshold of detection are shown below the dotted line and are not included in the geometric mean. C, Milk (n = 20) and peanut (n = 23)-specific components were plotted for IgE and IgG4. Where IgE and IgG4 were less than the detection limit, they were depicted with the values 0.25 kU/L and 0.04 μg/mL, respectively. Journal of Allergy and Clinical Immunology  , e5DOI: ( /j.jaci ) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig E1 Overview of study design. The number of individuals or sera that were tested is depicted. Sera that were tested are represented in boldface. Journal of Allergy and Clinical Immunology  , e5DOI: ( /j.jaci ) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Fig E2 Component-specific IgG4 to IgE ratio in sera that were positive to the component-relevant food by extract testing. In cases in which IgG4 or IgE was not detected, a ratio could not be calculated. IgE was normalized with the formula 1 kU/L = 2.4 ng/mL. Journal of Allergy and Clinical Immunology  , e5DOI: ( /j.jaci ) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Download ppt "Allergen sensitization in a birth cohort at midchildhood: Focus on food component IgE and IgG4 responses  Jeffrey M. Wilson, MD, PhD, Lisa Workman, BA,"

Similar presentations

Early exposure to cow's milk protein is protective against IgE-mediated cow's milk protein allergy Yitzhak Katz, MD, Nelly Rajuan, MSc, Michael R. Goldberg,

Early exposure to cow's milk protein is protective against IgE-mediated cow's milk protein allergy Yitzhak Katz, MD, Nelly Rajuan, MSc, Michael R. Goldberg,
Relationships among environmental exposures, cord blood cytokine responses, allergy, and wheeze at 1 year of age in an inner-city birth cohort (Urban.

Relationships among environmental exposures, cord blood cytokine responses, allergy, and wheeze at 1 year of age in an inner-city birth cohort (Urban.
Detection of novel occupational wood allergens in locust wood dust (Robinia pseudoacacia L.)  Sabine Kespohl, PhD, Rolf Merget, MD, Axel Overlack, MD,

Detection of novel occupational wood allergens in locust wood dust (Robinia pseudoacacia L.)  Sabine Kespohl, PhD, Rolf Merget, MD, Axel Overlack, MD,
Molecular spreading and predictive value of preclinical IgE response to Phleum pratense in children with hay fever  Laura Hatzler, Valentina Panetta,

Molecular spreading and predictive value of preclinical IgE response to Phleum pratense in children with hay fever  Laura Hatzler, Valentina Panetta,
The natural history of soy allergy

The natural history of soy allergy
Susan L. Limb, MD, Kathryn C. Brown, MD, Robert A. Wood, MD, Robert A

Susan L. Limb, MD, Kathryn C. Brown, MD, Robert A. Wood, MD, Robert A
Repeated low-dose intradermal allergen injection suppresses allergen-induced cutaneous late responses  Giuseppina Rotiroti, MD, Mohamed Shamji, PhD, Stephen.

Repeated low-dose intradermal allergen injection suppresses allergen-induced cutaneous late responses  Giuseppina Rotiroti, MD, Mohamed Shamji, PhD, Stephen.
Linear epitope mapping of peanut allergens demonstrates individualized and persistent antibody-binding patterns  Christian S. Hansen, PhD, Martin Dufva,

Linear epitope mapping of peanut allergens demonstrates individualized and persistent antibody-binding patterns  Christian S. Hansen, PhD, Martin Dufva,
Sensitization to cat and dog allergen molecules in childhood and prediction of symptoms of cat and dog allergy in adolescence: A BAMSE/MeDALL study  Anna.

Sensitization to cat and dog allergen molecules in childhood and prediction of symptoms of cat and dog allergy in adolescence: A BAMSE/MeDALL study  Anna.
Relevance of specific IgE antibody titer to the prevalence, severity, and persistence of asthma among 19-year-olds in northern Sweden  Matthew S. Perzanowski,

Relevance of specific IgE antibody titer to the prevalence, severity, and persistence of asthma among 19-year-olds in northern Sweden  Matthew S. Perzanowski,
Winter birth in inner-city asthmatic children is associated with increased food allergen sensitization risk  J. Andrew Bird, MD, Julie Wang, MD, Cynthia.

Winter birth in inner-city asthmatic children is associated with increased food allergen sensitization risk  J. Andrew Bird, MD, Julie Wang, MD, Cynthia.
Advances in Diagnosing Peanut Allergy

Advances in Diagnosing Peanut Allergy
A randomized, double-blind, placebo-controlled pilot study of sublingual versus oral immunotherapy for the treatment of peanut allergy  Satya D. Narisety,

A randomized, double-blind, placebo-controlled pilot study of sublingual versus oral immunotherapy for the treatment of peanut allergy  Satya D. Narisety,
High-titer IgE antibody specific for pollen allergens in northern California is associated with both wheezing and total serum IgE  Elizabeth A. Erwin,

High-titer IgE antibody specific for pollen allergens in northern California is associated with both wheezing and total serum IgE  Elizabeth A. Erwin,
Kyoung-Bok Min, MD, PhD, Jin-Young Min, PhD 

Kyoung-Bok Min, MD, PhD, Jin-Young Min, PhD 
The Natural History of Food Allergy

The Natural History of Food Allergy
Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD 

Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD 
Relevance of specific IgE antibody titer to the prevalence, severity, and persistence of asthma among 19-year-olds in northern Sweden  Matthew S. Perzanowski,

Relevance of specific IgE antibody titer to the prevalence, severity, and persistence of asthma among 19-year-olds in northern Sweden  Matthew S. Perzanowski,
Peanut, milk, and wheat intake during pregnancy is associated with reduced allergy and asthma in children  Supinda Bunyavanich, MD, MPH, Sheryl L. Rifas-Shiman,

Peanut, milk, and wheat intake during pregnancy is associated with reduced allergy and asthma in children  Supinda Bunyavanich, MD, MPH, Sheryl L. Rifas-Shiman,
Major rabbit allergen Ory c 3: What could be its possible role as a sensitizing agent in real life?  Gennaro Liccardi, MD, Antonello Salzillo, MD, Maria.

Major rabbit allergen Ory c 3: What could be its possible role as a sensitizing agent in real life?  Gennaro Liccardi, MD, Antonello Salzillo, MD, Maria.

Similar presentations

Ads by Google