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IgG and IgG4 to 91 allergenic molecules in early childhood by route of exposure and current and future IgE sensitization: Results from the Multicentre.

Published byΛυσιστράτη Βέργας Modified over 6 years ago

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Presentation on theme: "IgG and IgG4 to 91 allergenic molecules in early childhood by route of exposure and current and future IgE sensitization: Results from the Multicentre."— Presentation transcript:

1 IgG and IgG4 to 91 allergenic molecules in early childhood by route of exposure and current and future IgE sensitization: Results from the Multicentre Allergy Study birth cohort  Alina Schwarz, Valentina Panetta, MSc, Antonio Cappella, MD, Stephanie Hofmaier, MD, Laura Hatzler, MD, Alexander Rohrbach, Olympia Tsilochristou, MD, Carl-Peter Bauer, MD, Ute Hoffmann, MD, Johannes Forster, MD, Fred Zepp, MD, Antje Schuster, MD, Raffaele D'Amelio, MD, Ulrich Wahn, MD, Thomas Keil, MD, MSc, Susanne Lau, MD, Paolo Maria Matricardi, MD  Journal of Allergy and Clinical Immunology  Volume 138, Issue 5, Pages e12 (November 2016) DOI: /j.jaci Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Prevalence of IgG responses to 91 allergenic molecules in 148 children of the MAS cohort at 2 years of age by IgE sensitization at 2 years of age. Red and blue bars show the prevalence of detectable IgG responses (≥0.1 ISU) at 2 years of age in children with or without IgE sensitization at 2 years of age. P values were calculated with χ2 or exact Fisher tests, when appropriate. Significant differences are highlighted as follows: *P < .05, **P < .01, and ***P < .001. The column on the right represents the exposure category (animal foods [red], vegetable foods [orange], inhaled [yellow], and others [grey]) to which the allergenic sources of individual molecules belong. The marked boxes (#) refer to molecules used for analyses at the source level. Journal of Allergy and Clinical Immunology  , e12DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 Prevalence and levels of IgG responses to allergenic sources in 148 children of the MAS cohort at 2 years of age by IgE sensitization at 2 years of age and main exposure route. Circles show the prevalence (y-axis) and levels (diameter) of detectable IgG responses (≥0.1 ISU) to allergenic sources (see the Methods section for definition) at 2 years of age in children with (red) or without (blue) IgE sensitization at 2 years of age. P values refer to comparisons of the prevalences and levels and were calculated with a χ2 and t test, respectively. Statistically significant differences are highlighted as follows: *P < .05 for prevalence and °P < .05 for level. Dpt, D pteronyssinus. Journal of Allergy and Clinical Immunology  , e12DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig 3 Average prevalences and levels of IgG responses at 2 years of age to allergenic molecules by route of exposure in 123 nonsensitized and 25 IgE-sensitized 2-year-old children. Journal of Allergy and Clinical Immunology  , e12DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Fig E1 Molecule selection at the source and category level.
Journal of Allergy and Clinical Immunology  , e12DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

6 Fig E2 Prevalence of IgG4 responses (cutoff, 0.1 ISU) to allergenic molecules at 2 years of age in 148 children of the MAS cohort. Journal of Allergy and Clinical Immunology  , e12DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

7 Fig E3 Relationship between IgG (y-axis) and IgG4 (x-axis) levels to 91 allergenic molecules in a subset of 21 children of the MAS cohort. Each serum has been tested against the 91 molecules in parallel for IgG and IgG4 antibodies on the same day by the same operator. Overall, 1911 comparisons have been performed. Journal of Allergy and Clinical Immunology  , e12DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

8 Fig E4 Prevalence of IgG4 responses to allergenic molecules in 148 children of the MAS cohort at 2 years of age by means of IgE sensitization at 2 years of age. Only the molecules with at least 1 positive value (≥0.1 ISU) in either group are shown. P values were calculated with a χ2 test or exact Fisher test, when appropriate. Significant differences are highlighted as follows: *P < .05, **P < .01, and ***P < .001. Journal of Allergy and Clinical Immunology  , e12DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

9 Fig E5 Prevalence of IgG responses to allergenic molecules in 148 children of the MAS cohort at 2 years of age by IgE sensitization at 2 years of age. Only the results obtained in sera with no IgG4 response to the examined molecule have been taken into account. Therefore IgG4 antibodies do not contribute to the observed prevalence values. P values were calculated with a χ2 or exact Fisher test, when appropriate. Significant differences are highlighted as follows: *P < .05, **P < .01, and ***P < .001. Journal of Allergy and Clinical Immunology  , e12DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

10 Fig E6 Prevalence of IgG responses to 91 allergenic molecules at 2 years of age in 148 children of the MAS cohort by IgE sensitization at 7 years of age. Red and blue bars are the prevalence of detectable IgG responses (≥0.1 ISU) at 2 years of age in children with or without IgE sensitization at 7 years of age. P values were calculated with a χ2 or exact Fisher test, when appropriate. Statistically significant differences are highlighted as follows: *P < .05, **P < .01, and ***P < .001. Journal of Allergy and Clinical Immunology  , e12DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

11 Fig E7 Prevalence and levels of IgG responses to 9 allergenic sources at 2 years of age in 148 children of the MAS cohort by IgE sensitization to the same sources at 7 years of age. Red and blue bars represent the prevalence (left panels) and levels (right panels) at 2 years of age of detectable IgG responses (IgG, ≥0.1 ISU) to foodborne (upper panels) and airborne (lower panels) allergenic sources in children with (red) or without (blue) IgE sensitization to the same source at 7 years of age. P values refer to comparison of the prevalences and were calculated with χ2 or Fisher exact tests for the separate sources and with a 2-level logistic mixed model to take into account multiple data per subjects for the grouped sources. P values for geometric means were calculated with t tests for unpaired data on logarithmic values for separate sources and with a 2-level linear mixed model on log IgG levels. Statistically significant differences are highlighted as follows: *P < .05. Journal of Allergy and Clinical Immunology  , e12DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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