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Biochemistry Lecture 6
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Structure of Proteins
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Chapter 6, Figure 6.1, Three-dimensional folding of the protein myoglobin.
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Structural Groups
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Protein Folding
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Chapter 6, Figure 6.2, The four levels of structural organization of proteins
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Chapter 6, Figure 6.9, A Ramachandran plot of poly-L-alanine
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Keratin
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Collagen
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Chapter 6, Figure 6.14, The structure of collagen fibers
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Silk
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Globular Proteins
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X-Ray Crystallography
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Nuclear Magnetic Resonance
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Chapter 6, Figure 6A.9, Nuclear magnetic resonance spectroscopy (NMR)
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Quaternary Structure
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Folding and Denaturation
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Chapter 6, Figure 6.24, Contribution to the free energy of folding of globular proteins
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Monitoring Protein Folding
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Denaturation… also known as “Cooking”
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Chaperones
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Misfolding Diseases
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Mutation Impairs Proper Folding
Sickle Cell Anemia Cystic Fibrosis
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Contagious Misfolding: Prions
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