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Published byStig Christian Svensson Modified over 6 years ago
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A Canadian genome-wide association study and meta-analysis confirm HLA as a risk factor for peanut allergy independent of asthma Yuka Asai, MD, MSc, Aida Eslami, PhD, C. Dorien van Ginkel, BSc, Loubna Akhabir, PhD, Ming Wan, MSc, David Yin, George Ellis, BASc, Moshe Ben-Shoshan, MD, MSc, Ingo Marenholz, PhD, David Martino, MD, PhD, Manuel A. Ferreira, PhD, Katrina Allen, MD, PhD, Bruce Mazer, MD, Hans de Groot, MD, PhD, Nicolette W. de Jong, PhD, Roy Gerth van Wijk, MD, PhD, Anthony E.J. Dubois, MD, PhD, Sarah Grosche, MS, Sarah Ashley, PhD, Franz Rüschendorf, PhD, Birgit Kalb, MD, Kirsten Beyer, MD, Markus M. Nöthen, MD, Young-Ae Lee, MD, Rick Chin, MSc, Stephen Cheuk, MD, Joshua Hoffman, PhD, Eric Jorgensen, PhD, John S. Witte, PhD, Ronald B. Melles, MD, Xiumei Hong, MD, PhD, Xiaobin Wang, MD, MPH, ScD, Jennie Hui, PhD, Arthur W. (Bill) Musk, FRACP, Michael Hunter, PhD, Alan L. James, FRACP, Gerard H. Koppelman, MD, PhD, Andrew J. Sandford, PhD, Ann E. Clarke, MD, MSc, Denise Daley, PhD Journal of Allergy and Clinical Immunology Volume 141, Issue 4, Pages (April 2018) DOI: /j.jaci Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions
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Fig 1 Manhattan plot of genotyped and imputed SNPs on chromosome 6. Manhattan plot: Genotyped and imputed SNPs in 850 PA cases and 926 hypercontrol subjects. The x-axis denotes the genomic location, and the y-axis denotes the association level. The solid line indicates the threshold for genome-wide significance (P < 3.60 × 10−8), and the dashed line indicates the suggestive association significance threshold (P < 1.49 × 10−6). Imputed SNPs with P values of less than 1.49 × 10−6 are presented in gray. Journal of Allergy and Clinical Immunology , DOI: ( /j.jaci ) Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions
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Fig E1 Journal of Allergy and Clinical Immunology , DOI: ( /j.jaci ) Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions
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