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HLA-DPB1 and HLA Class I Confer Risk of and Protection from Narcolepsy

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Presentation on theme: "HLA-DPB1 and HLA Class I Confer Risk of and Protection from Narcolepsy"— Presentation transcript:

1 HLA-DPB1 and HLA Class I Confer Risk of and Protection from Narcolepsy
Hanna M. Ollila, Jean-Marie Ravel, Fang Han, Juliette Faraco, Ling Lin, Xiuwen Zheng, Giuseppe Plazzi, Yves Dauvilliers, Fabio Pizza, Seung-Chul Hong, Poul Jennum, Stine Knudsen, Birgitte R. Kornum, Xiao Song Dong, Han Yan, Heeseung Hong, Cristin Coquillard, Joshua Mahlios, Otto Jolanki, Mali Einen, Isabelle Arnulf, Birgit Högl, Birgit Frauscher, Catherine Crowe, Markku Partinen, Yu Shu Huang, Patrice Bourgin, Outi Vaarala, Alex Désautels, Jacques Montplaisir, Steven J. Mack, Michael Mindrinos, Marcelo Fernandez- Vina, Emmanuel Mignot  The American Journal of Human Genetics  Volume 96, Issue 1, Pages (January 2015) DOI: /j.ajhg Copyright © 2015 The American Society of Human Genetics Terms and Conditions

2 Figure 1 Association between HLA Loci and Narcolepsy
(A) Association of SNPs in the HLA region (Chr6: 29–36 Mb) reveals an overwhelming signal peaking at the level of HLA-DQB1 in white (from Immunochip, see Faraco et al.39) and chinese (from Affymetrix CHB data, see Han et al.5) individuals. Extended LD and association signal within the HLA-DR-DQ region obscure all other signals. (B) After conditioning for HLA-DRB1, HLA-DQA1, and HLA-DQB1 (significant alleles from the stepwise analysis), a residual association is seen in the HLA-DP region. (C) After conditioning for all significant HLA class II alleles, a remaining association is seen in the HLA class I region and is most visible proximal to HLA-B. A possible additional peak is seen in white individuals only in the vicinity of PSORS1. The American Journal of Human Genetics  , DOI: ( /j.ajhg ) Copyright © 2015 The American Society of Human Genetics Terms and Conditions

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