1. Faik Oruçoğlu (Orucov) Kudret Eye Hospital / Istanbul
Pachymetric changes during corneal collagen cross-linking and effect of hydroxipropylmethylcellulose on corneal thickness
Faik Oruçoğlu (Orucov)
Kudret Eye Hospital / Istanbul

2. Purpose
To evaluate central corneal pachymetric changes during corneal collagen cross-linking (CXL) and effect of hydroxipropylmethylcellulose (HPMC) drops.

3. Methods
Two groups were formed in patients with keratoconus undergoing cross-linking ;
Grup 1. (N=18).
Epithelial abrasion (9mm)
0.1 % Riboflavin drops in dextrane every 3 minutes for 30 minutes.
UVA 3mw/cm2 at 365nm for 30 min
Grup 2. (N=21).
0.1 % Riboflavin drops in dextrane every 3 minutes and hydroxipropylmethylcellulose (HPMC) every 5 minutes for 30 minutes.

4. before epithelial abrasion, after epithelial abrasion and
Central corneal thicknesses were measured by ultrasound pachimetry
before epithelial abrasion,
after epithelial abrasion and
30 minutes after beginning
riboflavin installation

5. Before epithelial abrasion After epithelial abrasion P
Grup 1
395±54,9
<0,001
Grup 2
389,4±44,2
0,009
After epithelial abrasion
30 minutes after riboflavin installation P
Grup 1
395±54,9
360±44,4
<0,001
Grup 2
389,4±44,2
374,4±38,1
0,08
450
440
430
420
410
400
390
380
370
360
Group 1
Group 2
After epithelial abrasion
30 minutes after riboflavin

6. Conclusion
Decrease of corneal thickness continues with epithelial peeling. This decrease in corneal thickness is significantly reduced by continuing the procedure with the addition of HPMC.
HPMC
Rb+Dextran
H2O
Rb+Dextran
H2O