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Unique spatiotemporal and dynamic gait compensations in the rat monoiodoacetate injection and medial meniscus transection models of knee osteoarthritis 

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Presentation on theme: "Unique spatiotemporal and dynamic gait compensations in the rat monoiodoacetate injection and medial meniscus transection models of knee osteoarthritis "— Presentation transcript:

1 Unique spatiotemporal and dynamic gait compensations in the rat monoiodoacetate injection and medial meniscus transection models of knee osteoarthritis  B.Y. Jacobs, K. Dunnigan, M. Pires-Fernandes, K.D. Allen  Osteoarthritis and Cartilage  Volume 25, Issue 5, Pages (May 2017) DOI: /j.joca Copyright © 2016 Osteoarthritis Research Society International Terms and Conditions

2 Fig. 1 Illustration of EDGAR setup; A: Side view of EDGAR with mirror and camera orientation; B: Floor design with instrumented panels A–D; C: Single frame from an animal trial video. Osteoarthritis and Cartilage  , DOI: ( /j.joca ) Copyright © 2016 Osteoarthritis Research Society International Terms and Conditions

3 Fig. 2 A: Right knee from an MMT group animal 4 weeks post-operation with a large lesion and some reduced staining of the articular cartilage; B: Right knee from an MIA animal 4 weeks post-injection with significant collapse of the articular surface; C: Naïve knee for reference. Osteoarthritis and Cartilage  , DOI: ( /j.joca ) Copyright © 2016 Osteoarthritis Research Society International Terms and Conditions

4 Fig. 3 A: Visual representation of MMT group spatial changes relative to control, where ellipse size indicates variance, horizontal lines indicate stride length, and vertical lines indicate step widths; B–D: Spatial symmetry, step width residuals, and stride length residuals of all animals in the MMT, MCLT, and skin incision groups. *: difference between indicated groups; 1–3: difference from indicated week. Osteoarthritis and Cartilage  , DOI: ( /j.joca ) Copyright © 2016 Osteoarthritis Research Society International Terms and Conditions

5 Fig. 4 A: Visual representation of MMT group temporal changes relative to control, shown as “Hildebrand plots” where percent indicates percent of a single gait cycle and light gray boxes indicate variance; B–D: Temporal symmetry, stance time imbalance, left percent stance time residuals, and right percent stance time residuals of all animals in the MMT, MCLT, and skin incision groups. *: difference between indicated groups; 1: difference from indicated week. Osteoarthritis and Cartilage  , DOI: ( /j.joca ) Copyright © 2016 Osteoarthritis Research Society International Terms and Conditions

6 Fig. 5 A–D: PVF (A–B) and z impulse (C–D) residual for the left and right feet of all animals in the MMT, MCLT, and skin incision groups; E: Visual representation of MMT group dynamic changes, where the x-axis represents stance time and the y-axis represents vertical force. *: difference between indicated groups; 1–3: difference from indicated week. Osteoarthritis and Cartilage  , DOI: ( /j.joca ) Copyright © 2016 Osteoarthritis Research Society International Terms and Conditions

7 Fig. 6 A: Visual representation of MIA group spatial changes relative to control, where ellipse size indicates variance, horizontal lines indicate stride length, and vertical lines indicate step widths; B–D: Spatial symmetry, step width residuals, and stride length residuals of all animals in the MIA and saline groups. *: difference between indicated groups; 1–3: difference from indicated week. Osteoarthritis and Cartilage  , DOI: ( /j.joca ) Copyright © 2016 Osteoarthritis Research Society International Terms and Conditions

8 Fig. 7 A: Visual representation of MIA group temporal changes relative to control, shown as “Hildebrand plots” where percent indicates percent of a single gait cycle and light gray boxes indicate variance; B–D: Temporal symmetry, stance time imbalance, left percent stance time residuals, and right percent stance time residuals of all animals in the MIA and saline groups. *: difference between indicated groups; 1–3: difference from indicated week. Osteoarthritis and Cartilage  , DOI: ( /j.joca ) Copyright © 2016 Osteoarthritis Research Society International Terms and Conditions

9 Fig. 8 A–D: (A–B) and z impulse (C–D) residual for the left and right feet of all animals in the MIA and saline groups; E: Visual representation of MMT group dynamic changes, where the x-axis represents stance time and the y-axis represents vertical force. *: difference between indicated groups; 1–3: difference from indicated week; f: difference between feet of the same group. Osteoarthritis and Cartilage  , DOI: ( /j.joca ) Copyright © 2016 Osteoarthritis Research Society International Terms and Conditions


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