Presentation is loading. Please wait.

Presentation is loading. Please wait.

Natalya A. Ortolano, Vivian Gama  Molecular Cell 

Published byDeddy Hadiman Modified over 5 years ago

Similar presentations

Presentation on theme: "Natalya A. Ortolano, Vivian Gama  Molecular Cell "— Presentation transcript:

1 Chronicle of a Neuronal Death Foretold: Preventing Aging by Keeping MGRN1 at the Nucleus 
Natalya A. Ortolano, Vivian Gama  Molecular Cell  Volume 66, Issue 3, Pages (May 2017) DOI: /j.molcel Copyright © 2017 Elsevier Inc. Terms and Conditions

2 Figure 1 MGRN1 Promotes a Transcriptional Stress Response in Aged Neurons Proteasomal activity decreases as neurons age. In young neurons with active proteasomes (left), MGRN1 remains localized in the cytoplasm. As proteotoxic stress builds (right), MGRN1 is deubiquitinated by the deubiquitinase (DUB) UCHL5 at the proteasome, producing a monoubiquitinated form of MGRN1. Monoubiquitinated MGRN1 translocates into the nucleus, promoting ATF3-dependent transcription of stress response genes. Illustration, Estefania Gama. Design, Natalya Ortolano and Megan Rasmussen. Molecular Cell  , DOI: ( /j.molcel ) Copyright © 2017 Elsevier Inc. Terms and Conditions

Download ppt "Natalya A. Ortolano, Vivian Gama  Molecular Cell "

Similar presentations

Structure of a Ubiquitin E1-E2 Complex: Insights to E1-E2 Thioester Transfer Shaun K. Olsen, Christopher D. Lima Molecular Cell Volume 49, Issue 5, Pages.

Structure of a Ubiquitin E1-E2 Complex: Insights to E1-E2 Thioester Transfer Shaun K. Olsen, Christopher D. Lima Molecular Cell Volume 49, Issue 5, Pages.
HnRNP L and HnRNP A1 Induce Extended U1 snRNA Interactions with an Exon to Repress Spliceosome Assembly Ni-Ting Chiou, Ganesh Shankarling, Kristen W. Lynch.

HnRNP L and HnRNP A1 Induce Extended U1 snRNA Interactions with an Exon to Repress Spliceosome Assembly Ni-Ting Chiou, Ganesh Shankarling, Kristen W. Lynch.
Individualized Medicine from Prewomb to Tomb Eric J. Topol Cell Volume 157, Issue 1, Pages 241-253 (March 2014) DOI: 10.1016/j.cell.2014.02.012 Copyright.

Individualized Medicine from Prewomb to Tomb Eric J. Topol Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell Copyright.
Mechanistic Insight into Site-Restricted Monoubiquitination of FANCD2 by Ube2t, FANCL, and FANCI Arno F. Alpi, Paul E. Pace, M. Madan Babu, Ketan J. Patel.

Mechanistic Insight into Site-Restricted Monoubiquitination of FANCD2 by Ube2t, FANCL, and FANCI Arno F. Alpi, Paul E. Pace, M. Madan Babu, Ketan J. Patel.
The Neurobiology of Decision: Consensus and Controversy Joseph W. Kable, Paul W. Glimcher Neuron Volume 63, Issue 6, Pages 733-745 (September 2009) DOI:

The Neurobiology of Decision: Consensus and Controversy Joseph W. Kable, Paul W. Glimcher Neuron Volume 63, Issue 6, Pages (September 2009) DOI:
What We Talk About When We Talk About Fat Evan D. Rosen, Bruce M. Spiegelman Cell Volume 156, Issue 1, Pages 20-44 (January 2014) DOI: 10.1016/j.cell.2013.12.012.

What We Talk About When We Talk About Fat Evan D. Rosen, Bruce M. Spiegelman Cell Volume 156, Issue 1, Pages (January 2014) DOI: /j.cell
An Ancient Mechanism for Splicing Control: U11 snRNP as an Activator of Alternative Splicing Jens Verbeeren, Elina H. Niemelä, Janne J. Turunen, Cindy.

An Ancient Mechanism for Splicing Control: U11 snRNP as an Activator of Alternative Splicing Jens Verbeeren, Elina H. Niemelä, Janne J. Turunen, Cindy.
Maintaining Cell Identity through Global Control of Genomic Organization Gioacchino Natoli Immunity Volume 33, Issue 1, Pages 12-24 (July 2010) DOI: 10.1016/j.immuni.2010.07.006.

Maintaining Cell Identity through Global Control of Genomic Organization Gioacchino Natoli Immunity Volume 33, Issue 1, Pages (July 2010) DOI: /j.immuni
The Pathobiology of Vascular Dementia Costantino Iadecola Neuron Volume 80, Issue 4, Pages 844-866 (November 2013) DOI: 10.1016/j.neuron.2013.10.008 Copyright.

The Pathobiology of Vascular Dementia Costantino Iadecola Neuron Volume 80, Issue 4, Pages (November 2013) DOI: /j.neuron Copyright.
Cost of Unneeded Proteins in E. coli Is Reduced after Several Generations in Exponential Growth Irit Shachrai, Alon Zaslaver, Uri Alon, Erez Dekel Molecular.

Cost of Unneeded Proteins in E. coli Is Reduced after Several Generations in Exponential Growth Irit Shachrai, Alon Zaslaver, Uri Alon, Erez Dekel Molecular.
Decision Making as a Window on Cognition Michael N. Shadlen, Roozbeh Kiani Neuron Volume 80, Issue 3, Pages 791-806 (October 2013) DOI: 10.1016/j.neuron.2013.10.047.

Decision Making as a Window on Cognition Michael N. Shadlen, Roozbeh Kiani Neuron Volume 80, Issue 3, Pages (October 2013) DOI: /j.neuron
Distinct Properties of Cell-Type-Specific and Shared Transcription Factor Binding Sites Jason Gertz, Daniel Savic, Katherine E. Varley, E. Christopher.

Distinct Properties of Cell-Type-Specific and Shared Transcription Factor Binding Sites Jason Gertz, Daniel Savic, Katherine E. Varley, E. Christopher.
Telomeric Noncoding RNA TERRA Is Induced by Telomere Shortening to Nucleate Telomerase Molecules at Short Telomeres Emilio Cusanelli, Carmina Angelica.

Telomeric Noncoding RNA TERRA Is Induced by Telomere Shortening to Nucleate Telomerase Molecules at Short Telomeres Emilio Cusanelli, Carmina Angelica.
Neuronal Cell Types and Connectivity: Lessons from the Retina H. Sebastian Seung, Uygar Sümbül Neuron Volume 83, Issue 6, Pages 1262-1272 (September 2014)

Neuronal Cell Types and Connectivity: Lessons from the Retina H. Sebastian Seung, Uygar Sümbül Neuron Volume 83, Issue 6, Pages (September 2014)
Human Brown Adipose Tissue Sven Enerbäck Cell Metabolism Volume 11, Issue 4, Pages 248-252 (April 2010) DOI: 10.1016/j.cmet.2010.03.008 Copyright © 2010.

Human Brown Adipose Tissue Sven Enerbäck Cell Metabolism Volume 11, Issue 4, Pages (April 2010) DOI: /j.cmet Copyright © 2010.
Molecular Motors in Neurons: Transport Mechanisms and Roles in Brain Function, Development, and Disease Nobutaka Hirokawa, Shinsuke Niwa, Yosuke Tanaka.

Molecular Motors in Neurons: Transport Mechanisms and Roles in Brain Function, Development, and Disease Nobutaka Hirokawa, Shinsuke Niwa, Yosuke Tanaka.
The BCL-2 Family Reunion Jerry E. Chipuk, Tudor Moldoveanu, Fabien Llambi, Melissa J. Parsons, Douglas R. Green Molecular Cell Volume 37, Issue 3, Pages.

The BCL-2 Family Reunion Jerry E. Chipuk, Tudor Moldoveanu, Fabien Llambi, Melissa J. Parsons, Douglas R. Green Molecular Cell Volume 37, Issue 3, Pages.
Pyramidal Neurons Grow Up and Change Their Mind Gord Fishell, Carina Hanashima Neuron Volume 57, Issue 3, Pages 333-338 (February 2008) DOI: 10.1016/j.neuron.2008.01.018.

Pyramidal Neurons Grow Up and Change Their Mind Gord Fishell, Carina Hanashima Neuron Volume 57, Issue 3, Pages (February 2008) DOI: /j.neuron
The Mitochondrial Basis of Aging Nuo Sun, Richard J. Youle, Toren Finkel Molecular Cell Volume 61, Issue 5, Pages 654-666 (March 2016) DOI: 10.1016/j.molcel.2016.01.028.

The Mitochondrial Basis of Aging Nuo Sun, Richard J. Youle, Toren Finkel Molecular Cell Volume 61, Issue 5, Pages (March 2016) DOI: /j.molcel
E3-Independent Monoubiquitination of Ubiquitin-Binding Proteins Daniela Hoeller, Christina-Maria Hecker, Sebastian Wagner, Vladimir Rogov, Volker Dötsch,

E3-Independent Monoubiquitination of Ubiquitin-Binding Proteins Daniela Hoeller, Christina-Maria Hecker, Sebastian Wagner, Vladimir Rogov, Volker Dötsch,

Similar presentations

Ads by Google