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Volume 63, Issue 6, Pages (June 2003)

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Presentation on theme: "Volume 63, Issue 6, Pages (June 2003)"— Presentation transcript:

1 Volume 63, Issue 6, Pages 2262-2268 (June 2003)
Elevation of blood thioredoxin in hemodialysis patients with hepatitis C virus infection  Akihiko Kato, Mari Odamaki, Hajime Nakamura, Junji Yodoi, Akira Hishida  Kidney International  Volume 63, Issue 6, Pages (June 2003) DOI: /j t x Copyright © 2003 International Society of Nephrology Terms and Conditions

2 Figure 1 Serum thioredoxin (TRX) in hemodialysis (HD) patients. A significant increase in blood TRX is present in HD patients without hepatitis C virus (HCV) infection compared to normal subjects. TRX was increased to a greater extent in patients with HCV infection than those without HCV infection. Kidney International  , DOI: ( /j t x) Copyright © 2003 International Society of Nephrology Terms and Conditions

3 Figure 2 Blood thioredoxin (TRX) and serum asparate aminotransferase (AST) in dialysis patients with (A) and without (B) hepatitis C viremia (HCV). TRX was significantly and positively correlated with AST, both in patients with (N = 59) and without hepatitis C virus infection (N = 85). Kidney International  , DOI: ( /j t x) Copyright © 2003 International Society of Nephrology Terms and Conditions

4 Figure 3 Blood ferritin and oxidative stress markers in hepatitis C virus (HCV)-infected dialysis patients. Serum ferritin was significantly and positively associated with thioredoxin (TRX) and malondialdehyde (MDA) in patients with chronic HCV infection (N = 89). Kidney International  , DOI: ( /j t x) Copyright © 2003 International Society of Nephrology Terms and Conditions

5 Figure 4 Iron injection and blood thioredoxin (TRX) in hemodialysis patients. Hemodialysis patients receiving weekly iron injection (40 mg, intravenously) have a higher TRX level compared to those without iron supplement, both in patients with and without hepatitis C virus (HCV) infection. Kidney International  , DOI: ( /j t x) Copyright © 2003 International Society of Nephrology Terms and Conditions


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