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Christopher J. Tabone, Mani Ramaswami  Neuron 

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Presentation on theme: "Christopher J. Tabone, Mani Ramaswami  Neuron "— Presentation transcript:

1 Is NMDA Receptor-Coincidence Detection Required for Learning and Memory? 
Christopher J. Tabone, Mani Ramaswami  Neuron  Volume 74, Issue 5, Pages (June 2012) DOI: /j.neuron Copyright © 2012 Elsevier Inc. Terms and Conditions

2 Figure 1 The NMDA Receptor Mg2+ Block Regulates dCREB2-b Activity and Long-Term Memory Formation The Mg2+ block reduces baseline calcium entry and prevents basal activation of dCREB2-b, thereby keeping neurons in a state permissive for activity-induced transcription required for LTM. Removal of the NMDAR Mg2+ block in dNR1(N631Q) flies causes increased baseline calcium signaling that causes a 4-fold increase in dCREB2-b expression and a subsequent strong repression of the LTM-associated genes staufen, activin, and homer. This prevents CREB-dependent plasticity required for LTM formation. (Illustration is by Jens Hillebrand.) Neuron  , DOI: ( /j.neuron ) Copyright © 2012 Elsevier Inc. Terms and Conditions

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