1. Epithelial Homeostasis: A Piezo of the Puzzle
Eugenia Piddini 
Current Biology 
Volume 27, Issue 6, Pages R232-R234 (March 2017)
DOI: /j.cub
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2. Figure 1 Piezo1 mediates stretch-induced proliferation.
Epithelial cell stretching induces opening of the stretch-activated calcium channel Piezo1. Calcium influx activates the calcium-sensitive kinase ERK1, which in turn causes cells that were in the G2 phase of the cell cycle to enter mitosis. Through this mechanism, epithelia react to stretching with a quick burst of cell divisions that counters the decrease in cell density.
Current Biology  , R232-R234DOI: ( /j.cub )
Copyright © 2017 Elsevier Ltd Terms and Conditions