Download presentation
Presentation is loading. Please wait.
1
The Highway to Hell: A RIP Kinase-Directed Shortcut to Inflammatory Cytokine Production
Joanne M. Hildebrand, James M. Murphy Immunity Volume 45, Issue 1, Pages 1-3 (July 2016) DOI: /j.immuni Copyright © 2016 Elsevier Inc. Terms and Conditions
2
Figure 1 The RIPK1-RIPK3 Necrosome Triggers Both Inflammatory Cytokine Production and Necroptosis Downstream of TLR4-TRIF While necrosome mediated Erk1/2 phosphorylation and MLKL phosphorylation is concurrent, Erk1/2 induces inflammatory gene induction at break-neck speed while MLKL takes a more meandering path to necroptotic membrane destruction. Immunity , 1-3DOI: ( /j.immuni ) Copyright © 2016 Elsevier Inc. Terms and Conditions
Similar presentations
© 2024 SlidePlayer.com. Inc.
All rights reserved.