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Remodeling Amyloid Fibers: Baker’s Yeast Shows Us the Way

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Presentation on theme: "Remodeling Amyloid Fibers: Baker’s Yeast Shows Us the Way"— Presentation transcript:

1 Remodeling Amyloid Fibers: Baker’s Yeast Shows Us the Way
Eva Asp, Ming Proschitsky, Rajaraman Krishnan  Chemistry & Biology  Volume 22, Issue 8, Pages (August 2015) DOI: /j.chembiol Copyright © 2015 Elsevier Ltd Terms and Conditions

2 Figure 1 Hsp104 Mediated Clustering and Remodeling of Seminal Amyloids
Hsp104 mediated remodeled aggregates can be degraded efficiently in the presence of cellular proteases. Chemistry & Biology  , DOI: ( /j.chembiol ) Copyright © 2015 Elsevier Ltd Terms and Conditions

3 Figure 2 Schematic Representation of Amyloid Remodeling Nanomachines
The substrate binding domain (SBD) and conformational change inducing domain (CID) work in tandem to bind and remodel fibers. SlyD, g3p, and FkpA are alternate scaffolds that can be engineered to bind and remodel aggregates. Chemistry & Biology  , DOI: ( /j.chembiol ) Copyright © 2015 Elsevier Ltd Terms and Conditions

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