1. Volume 139, Issue 3, Pages 836-845.e1 (September 2010)
Genetic Covariance Between γ-Glutamyl Transpeptidase and Fatty Liver Risk Factors: Role of β2-Adrenergic Receptor Genetic Variation in Twins 
Rohit Loomba, Fangwen Rao, Lian Zhang, Srikrishna Khandrika, Michael G. Ziegler, David A. Brenner, Daniel T. O'Connor 
Gastroenterology 
Volume 139, Issue 3, Pages e1 (September 2010)
DOI: /j.gastro
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2. Figure 1
Heritability (h2) estimates of γ-glutamyl transpeptidase (GGT) and fatty liver risk factors are shown in the present twin cohort. These h2 estimates (±standard error of mean) are similar to previously published studies, suggesting generalizability of findings from our cohort. GGT has substantial heritability, at 49% ± 8%. BMI, body mass index; DBP, diastolic blood pressure; LDL, low-density lipoprotein.
Gastroenterology  , e1DOI: ( /j.gastro )
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3. Figure 2
Linkage disequilibrium (LD) across the β2-adrenergic receptor (ADRB2) locus using Haploview. Darker block color denotes stronger pair-wise correlation among single nucleotide polymorphisms, within one major LD block.
Gastroenterology  , e1DOI: ( /j.gastro )
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4. Figure 3
(A) β2-adrenergic receptor (ADRB2) haplotype-1 (AGGCCGGGC) effect on γ-glutamyl transpeptidase (GGT) in age-/sex-adjusted models. Results demonstrate a significant association (P < .024), suggesting that ADRB2 plays a role in regulation of GGT secretion. (B) ADRB2 haplotype-1 (AGGCCGGGC) increases both GGT and triglycerides in plasma. Results illustrate the pleiotropic effect of ADRB2 genetic variation on fatty liver risk factors.
Gastroenterology  , e1DOI: ( /j.gastro )
Copyright © 2010 AGA Institute Terms and Conditions

5. Supplementary Figure 1
ADRB2 haplotype (AGGCCGGGC) excluding HWE-violating SNP (T-47C) increases both GGT and triglycerides in plasma. Results illustrate the pleiotropic effect of ADRB2 genetic variation on fatty liver risk factors.
Gastroenterology  , e1DOI: ( /j.gastro )
Copyright © 2010 AGA Institute Terms and Conditions