1. Prevalence of elevated liver enzymes in children with cystic fibrosis diagnosed by newborn screen 
Samantha A. Woodruff, Marci K. Sontag, Frank J. Accurso, Ronald J. Sokol, Michael R. Narkewicz 
Journal of Cystic Fibrosis 
Volume 16, Issue 1, Pages (January 2017)
DOI: /j.jcf
Copyright © 2016 European Cystic Fibrosis Society. Terms and Conditions

2. Fig. 1
Serial determination of serum AST (A), ALT (B) and GGT (C) concentrations for all CF subjects by age (months) at all visits. The solid line represents the upper limit of normal for age (ULN).
Journal of Cystic Fibrosis  , DOI: ( /j.jcf )
Copyright © 2016 European Cystic Fibrosis Society. Terms and Conditions

3. Fig. 2
Proportion of individuals who have not had an abnormal (elevated) liver enzyme at an annual visit by age (stratified by any elevation, ≥1.5× upper limit of normal for age (ULN), ≥2× ULN, ≥3× ULN). Panel A: Time to first elevated AST, Panel B: Time to second elevated AST at least 6months after first, Panel C: Time to first elevated ALT, Panel D: Time to second elevated ALT at least 6months after first, Panel E: Time to first elevated GGT Panel F: Time to second elevated GGT at least 6months after first.
Journal of Cystic Fibrosis  , DOI: ( /j.jcf )
Copyright © 2016 European Cystic Fibrosis Society. Terms and Conditions

4. Fig. 3
Proportion of individuals who had not had an elevated liver enzyme at an annual visit ≥1.5× upper limit of normal for age (ULN) of GGT, AST or ALT, stratified by risk factor. Panels a–c) Female sex, d–f) Hispanic Ethnicity, g–i) Meconium ileus, and j–l) CFTR Mutation Severity (severe (both mutations of class 1, 2 or 3) vs. milder (at least one class 4 or 5 mutation)).
Journal of Cystic Fibrosis  , DOI: ( /j.jcf )
Copyright © 2016 European Cystic Fibrosis Society. Terms and Conditions