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Maya Gambarin–Gelwan, Sanjiv V. Kinkhabwala, Thomas D

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Presentation on theme: "Maya Gambarin–Gelwan, Sanjiv V. Kinkhabwala, Thomas D"— Presentation transcript:

1 Prevalence of Nonalcoholic Fatty Liver Disease in Women With Polycystic Ovary Syndrome 
Maya Gambarin–Gelwan, Sanjiv V. Kinkhabwala, Thomas D. Schiano, Carol Bodian, Hsu–Chong Yeh, Walter Futterweit  Clinical Gastroenterology and Hepatology  Volume 5, Issue 4, Pages (April 2007) DOI: /j.cgh Copyright © 2007 AGA Institute Terms and Conditions

2 Figure 1 Ultrasonographic criteria for severity of hepatic steatosis. (A) ABSENT: the echogenicity of the liver parenchyma is slightly greater or equal to that of the renal cortex; clear visualization of the diaphragm and intrahepatic vessels; (B) MILD: slight diffuse increase in fine echoes in the liver parenchyma with normal visualization of the diaphragm and intrahepatic vessel borders; (C) MODERATE: moderate diffuse increase in fine echoes in the liver parenchyma with slightly impaired visualization of intrahepatic vessels and diaphragm; (D) SEVERE: marked increase in fine echoes with poor or nonvisualization of the intrahepatic vessel borders, diaphragm, and posterior or deep portion of the right lobe of the liver. Clinical Gastroenterology and Hepatology 2007 5, DOI: ( /j.cgh ) Copyright © 2007 AGA Institute Terms and Conditions

3 Figure 2 Prevalence and severity of hepatic steatosis according to the BMI group. (▨) Denotes estimated population-based prevalence of hepatic steatosis by the ultrasonographic criteria.16,31,32 Clinical Gastroenterology and Hepatology 2007 5, DOI: ( /j.cgh ) Copyright © 2007 AGA Institute Terms and Conditions

4 Figure 3 Prevalence of steatosis by HOMA-IR quartile. Patients in the higher HOMA-IR (fasting glucose × fasting insulin/450) quartiles had significantly higher prevalence and higher severity of steatosis. Clinical Gastroenterology and Hepatology 2007 5, DOI: ( /j.cgh ) Copyright © 2007 AGA Institute Terms and Conditions

5 Figure 4 Prevalence of elevated ALT or γ-glutamyltransferase (GGT) according to the BMI group and grade of hepatic steatosis. More obese women have abnormal liver enzymes compared with lean women (P < .05). Patients with steatosis are more likely to have abnormal liver enzymes (P < .01), as do patients with severe compared with moderate steatosis (P < .05). Clinical Gastroenterology and Hepatology 2007 5, DOI: ( /j.cgh ) Copyright © 2007 AGA Institute Terms and Conditions


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