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Figure 2 The patterns of epithelial-to-mesenchymal

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Presentation on theme: "Figure 2 The patterns of epithelial-to-mesenchymal"— Presentation transcript:

1 Figure 2 The patterns of epithelial-to-mesenchymal
transition (EMT)-programme activation during carcinoma progression Figure 2 | The patterns of epithelial-to-mesenchymal transition (EMT)-programme activation during carcinoma progression. a | In primary tumours, activation of the EMT programme enables particular carcinoma cells to invade the surrounding stroma; some of these cells eventually enter the systemic circulation. b | Circulating tumour cells can demonstrate epithelial and/or mesenchymal traits. Indeed, cancer cells in the circulation, whether solitary or in clusters, frequently exhibit signs of at least partial EMT82. c | Reversal of the EMT process — that is, activation of the mesenchymal-to-epithelial transition (MET) programme — following dissemination of carcinoma cells to distant tissues seems to be critical for the outgrowth of metastases from many types of carcinoma88,89. Shibue, T. & Weinberg, R. A. (2017) EMT, CSCs, and drug resistance: the mechanistic link and clinical implications Nat. Rev. Clin. Oncol. doi: /nrclinonc

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