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Nat. Rev. Nephrol. doi:10.1038/nrneph.2016.186
Figure 4 Potential strategies for the assessment of renal tolerance in patients with sepsis Figure 4 | Potential strategies for the assessment of renal tolerance in patients with sepsis. a | Determination of tolerance (that is, reaction norms) could potentially be achieved at the bedside using existing kidney-specific markers of renal fitness and clinical surrogates of pathogen load. b | An alternative, potentially more feasible approach might be to determine the impact of immunopathology on renal fitness using clinical surrogates of inflammatory burden. CRP, C-reactive protein; IGFBP-7, insulin-like growth factor-binding protein; LPS, lipopolysaccharide; NGAL, neutrophil gelatinase-associated lipocalin; TIMP-2, urinary metalloproteinase inhibitor 2. Gómez, H. et al. (2017) Metabolic reprogramming and tolerance during sepsis-induced AKI Nat. Rev. Nephrol. doi: /nrneph
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