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TERT Promoter Mutations in Skin Cancer: The Effects of Sun Exposure and X- Irradiation  Helena Pópulo, Paula Boaventura, João Vinagre, Rui Batista, Adélia.

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Presentation on theme: "TERT Promoter Mutations in Skin Cancer: The Effects of Sun Exposure and X- Irradiation  Helena Pópulo, Paula Boaventura, João Vinagre, Rui Batista, Adélia."— Presentation transcript:

1 TERT Promoter Mutations in Skin Cancer: The Effects of Sun Exposure and X- Irradiation 
Helena Pópulo, Paula Boaventura, João Vinagre, Rui Batista, Adélia Mendes, Regina Caldas, Joana Pardal, Filomena Azevedo, Mrinalini Honavar, Isabel Guimarães, José Manuel Lopes, Manuel Sobrinho-Simões, Paula Soares  Journal of Investigative Dermatology  Volume 134, Issue 8, Pages (August 2014) DOI: /jid Copyright © 2014 The Society for Investigative Dermatology, Inc Terms and Conditions

2 Figure 1 Kaplan–Meier curves for disease-free and overall survival of cutaneous melanoma patients. Kaplan–Meier curves demonstrating the correlation between telomerase (TERT) promoter mutations and disease-free (a) and overall (b) survival of cutaneous melanoma patients. Patients with TERT promoter mutations (solid line) display significantly (P=0.04) reduced disease-free and overall survival compared with patients without TERT mutations (dashed line). Journal of Investigative Dermatology  , DOI: ( /jid ) Copyright © 2014 The Society for Investigative Dermatology, Inc Terms and Conditions

3 Figure 2 Telomerase expression in melanoma. Telomerase (TERT) expression in acral (a), lentigo maligna (b), nodular (c), and superficial spreading (d) melanoma subtypes. DAB. Scale bars=200 μm (a–d). Journal of Investigative Dermatology  , DOI: ( /jid ) Copyright © 2014 The Society for Investigative Dermatology, Inc Terms and Conditions


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