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Topography in Hippocampal Mossy Fiber Plasticity

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Presentation on theme: "Topography in Hippocampal Mossy Fiber Plasticity"— Presentation transcript:

1 Topography in Hippocampal Mossy Fiber Plasticity
Rüdiger Klein  Neuron  Volume 65, Issue 5, Pages (March 2010) DOI: /j.neuron Copyright © 2010 Elsevier Inc. Terms and Conditions

2 Figure 1 Schematic Drawing of Mossy Fibers and Their Terminal Arborizations Each mossy fiber originates from a dentate gyrus (DG) granule cell (GC). Three GCs are shown (numbered 1–3). Mossy fibers have approximately a dozen large mossy fiber terminals (LMTs) and often only a single distinct TA. TA specification follows certain topography principles: GCs of the upper blade (1) establish TAs in distal CA3 (TA1); GCs at the crest of the DG (2) establish TAs half-way along the CA3 (TA2); GCs of the lower blade (3), where EphA4 expression is highest, establish TAs in proximal CA3 (TA3). (Inset) Each TA consists of a core LMT, satellite LMTs, and of processes. Filopodia synapse onto inhibitory interneurons. Neuron  , DOI: ( /j.neuron ) Copyright © 2010 Elsevier Inc. Terms and Conditions

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