1. Volume 154, Issue 4, Pages 848-861 (October 2018)
Psychometric Validation of the Pulmonary Arterial Hypertension-Symptoms and Impact (PAH-SYMPACT) Questionnaire 
Kelly M. Chin, MD, Mardi Gomberg-Maitland, MD, Richard N. Channick, MD, Michael J. Cuttica, MD, Aryeh Fischer, MD, Robert P. Frantz, MD, Elke Hunsche, PhD, Leah Kleinman, DrPH, John W. McConnell, MD, Vallerie V. McLaughlin, MD, Chad E. Miller, MD, Roham T. Zamanian, MD, Michael S. Zastrow, PhD, David B. Badesch, MD 
CHEST 
Volume 154, Issue 4, Pages (October 2018)
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2. Figure 1
Development and validation studies of the PAH-SYMPACT. ICF = informed consent form; PAH = pulmonary arterial hypertension; PAH-SYMPACT = Pulmonary Arterial Hypertension-Symptoms and Impact Questionnaire; PRO = patient-reported outcome; SYMPHONY = A Study of Macitentan in Pulmonary Arterial Hypertension to Validate the PAH-SYMPACT. aPreviously published by McCollister et al.13
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3. Figure 2
Assessment schedule in SYMPHONY. 6MWT = 6-min walk test; CAMPHOR = Cambridge Pulmonary Hypertension Outcome Review; CGI-C = Clinician Global Impression of Change; CGI-S = Clinician Global Impression of Severity; ePRO = electronic version of PAH-SYMPACT; FC = functional class; PGA-S = Patient Global Assessment of Disease Severity; SF-36 = 36-item Medical Outcomes Study Short Form Survey. See Figure 1 legend for expansion of other abbreviations.
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4. Figure 3
Conceptual framework of the revised PAH-SYMPACT. See Figure 1 legend for expansion of abbreviations.
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5. Figure 4
Domain scores (ePRO period 2) according to functional class (visit 2). LS = least squares. Data are presented as least squares mean ± SE. Pairwise comparisons between least squares means were performed by using the Scheffé test, adjusting for multiple comparisons; only statistically significant pairwise comparisons are shown. *P < .05. **P < ***P < See Figure 1 and 2 legends for expansion of abbreviations.
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6. Figure 5
Change over time in domain scores (ePRO period 2 to period 4) by change in PGA-S score (visit 2 to visit 4). Data are presented as least squares mean ± SE. Pairwise comparisons between least squares means were performed by using the Scheffé test, adjusting for multiple comparisons; only statistically significant pairwise comparisons are shown. **P < ***P < See Figure 2 for definitions of visits and ePRO periods. See Figure 1 and 2 legends for expansion of abbreviations.
CHEST  , DOI: ( /j.chest )
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