1. Synapse

2. Synapse

3. Electrical Synapse

4. Chemical Synapse

5. Electrical vs. Chemical

6. Synaptic vesicle

7. Synaptic vesicle

8. Synaptic vesicle

9. Synaptic cleft

10. Synaptic cleft

11. Some common neurotransmitters
Action Receptors
Acetylcholine (Ach) +/- Nicotinic, Muscarinic
Norepinephrine (NE) + a1, a2, b1, b2
Dopamine (DA) +/- D1,D2
Glutamate (Glu) + NMDA, AMPA
Serotonin (5-HT) +/- 5-HT1, etc
GABA GABA1, GABA2
Opioids (Enkephalin) - m,d,k

12. Neurotransmitter

13. Neurotransmitter

14. Glutamate receptor

15. Glutamate receptor

16. GABA receptor

17. GABA receptor

18. GABA receptor

19. Drug effects on receptor

20. Serotonin-Selective Reuptake Block

21. Postsynaptic potential

22. Long term potentiation

23. Long term potentiation

24. Long term potentiation

25. Long term depression

26. Synaptic inhibition

27. Neuromuscular junction

28. Postsynaptic response

29. Nicotinic receptor

30. Acetylcholine metabolism

31. Various receptors

32. Take home message