1. TIGP: Computing biology II - Analysis of Categorical Data
Hsuan-Yu Chen
Institute of Statistical Science, Academia Sinica

2. Textbooks:
Rosner, B. (2000), Fundamentals of Biostatistics (5th Edition), Duxbury, Pacific Grove
Rothman and Greenland (1998), Modern Epidemiology (2nd Edition), Lippincott-Raven, Philadelphia
The sides are extracted from textbooks.

3. Prospective study
measurement
onset
Time
Time
baseline

4. Retrospective study
disease
normal
sampling

5. Incidence proportion

14. Question 1:
proof
Question 2:
Small sample methods for single study and two study groups, respectively

15. Two-sample test for binomial proportions

30. 30

32. 32

38. Question 3:
Find a R X C table and test the association of two variables
Question 4:
Perform the trend test for above R X C table

40. Fisher’s Exact Test

46. 2 23 25 5 30 35 7 53 60

55. followed chi-square distribution under Ho
Question 5
proof
followed chi-square distribution under Ho
Question 6
If ND/4 <5, please using exact test to compute the p value

62. κ > 0.75 excellent reproducibility
0.4 < κ ≦ 0.75 good reproducibility
0 ≦ κ < 0.4 marginal reproducibility

63. Question 7
proof