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Pivotal Data Highlights on Myeloproliferative Neoplasms Myelofibrosis

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Presentation on theme: "Pivotal Data Highlights on Myeloproliferative Neoplasms Myelofibrosis"— Presentation transcript:

1 Pivotal Data Highlights on Myeloproliferative Neoplasms Myelofibrosis

2 Activity Goals

3 Prognosis: CALR MF is a Distinct Entity

4 Clinical Effect of Founding Driver Mutations in MF

5 Phase 1b: Panobinostat and Ruxolitinib in MF

6 Novel Combination: PRM-151 + RUX

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13 ET: Molecular Markers

14 ET: Impact of Treatment on Molecular Markers

15 Prognosis and Risk Stratification

16 Splanchnic Vein Thrombosis

17 Pivotal Data Highlights on Acute Myeloid Leukemia FLT3 Inhibition

18 Phase 2: Efficacy of Quizartinib in Relapsed/ Refractory AML

19 Quizartinib as a Bridge to HCT in FLT3-ITD(+) AML

20 Pivotal Data Highlights on Acute Myeloid Leukemia New Agents for Older Patients

21 Phase I/2 Study of Volasertib

22 Phase 2:Efficacy and Safety of SGI-110

23 Abbreviations

24 Abbreviations (cont)

25 Abbreviations (cont)

26 References

27 References (cont)

28 References (cont)

29 References (cont)

30 References (cont)

31 References (cont)

32 References (cont)

33 References (cont)

34 References (cont)

35 References (cont)


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