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The EGLN-HIF O2-Sensing System: Multiple Inputs and Feedbacks

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Presentation on theme: "The EGLN-HIF O2-Sensing System: Multiple Inputs and Feedbacks"— Presentation transcript:

1 The EGLN-HIF O2-Sensing System: Multiple Inputs and Feedbacks
Mircea Ivan, William G. Kaelin  Molecular Cell  Volume 66, Issue 6, Pages (June 2017) DOI: /j.molcel Copyright © Terms and Conditions

2 Figure 1 Model of Cooperation between Coding Genes and miR-210 Downstream of HIF1 Feedback loop leading to renormalization of local O2 tension as a result of decreased local consumption. Molecular Cell  , DOI: ( /j.molcel ) Copyright © Terms and Conditions

3 Figure 2 Model of Noncoding RNA-Based Feedback Circuits Optimizing the Transition from an HIF1- to an HIF2-Based Hypoxic Response Molecular Cell  , DOI: ( /j.molcel ) Copyright © Terms and Conditions

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